公开(公告)号：US06911562B2

公开(公告)日：2005-06-28

申请号：US10887396

申请日：2004-07-08

申请人： Ramachandra Bhat ,  Vinodkumar Ramniranjan Dhanuka ,  Bijan Harichian

发明人： Ramachandra Bhat ,  Vinodkumar Ramniranjan Dhanuka ,  Bijan Harichian

IPC分类号： C07C37/00 ,  C07C39/08

CPC分类号： C07C37/002 ,  C07C39/08

摘要： A process for the preparation of a compound of formula I: wherein R is a hydrogen or a C1-6 alkyl group which is straight chain, branched or cyclic, with or without an oxygen, nitrogen or sulphur heteroatom anywhere in the chain or ring by reacting a compound of formula II: with a source of hydrogen selected from either hydrogen or water in the presence of a mixture of at least two catalysts selected from nickel, raney nickel, and palladium, at a pH below 7.0 in a solvent medium comprising an alcohol having a carbon chain length of up to 3.

摘要翻译： 制备式I化合物的方法：其中R是直链，支链或环状的氢或C 1-6烷基，具有或不具有氧，氮或硫 通过在选自镍，雷尼镍和钯的至少两种催化剂的混合物存在下，使式II化合物与选自氢或水的氢源反应，在链或环中的任意位置处的杂原子， 在包含碳链长度高达3的醇的溶剂介质中低于7.0。

公开(公告)号：US20050054884A1

公开(公告)日：2005-03-10

申请号：US10887396

申请日：2004-07-08

申请人： Ramachandra Bhat ,  Vinodkumar Dhanuka ,  Bijan Harichaian

发明人： Ramachandra Bhat ,  Vinodkumar Dhanuka ,  Bijan Harichaian

IPC分类号： C07C37/00 ,  C07C39/08 ,  C07C43/20

CPC分类号： C07C37/002 ,  C07C39/08

摘要： A process for the preparation of a compound of formula I: wherein R is a hydrogen or a C1-6 alkyl group which is straight chain, branched or cyclic, with or without an oxygen, nitrogen or sulphur heteroatom anywhere in the chain or ring by reacting a compound of formula II: with a source of hydrogen selected from either hydrogen or water in the presence of a mixture of at least two catalysts selected from nickel, raney nickel, and palladium, at a pH below 7.0 in a solvent medium comprising an alcohol having a carbon chain length of up to 3.

摘要翻译： 制备式I化合物的方法：其中R是直链，支链或环状的氢或C 1-6烷基，具有或不具有氧，氮或硫杂原子的链或环中的任何地方，通过 在选自镍，雷尼镍和钯的至少两种催化剂的混合物存在下，在pH低于7.0的溶剂介质中，将式Ⅱ化合物与选自氢或水的氢源反应： 碳链长度可达3的醇。