公开(公告)号：US20130072518A1

公开(公告)日：2013-03-21

申请号：US13499998

申请日：2009-12-31

申请人： Ramakrishna Nirogi ,  Abdul Rasheed Mohammed ,  Srinivas Veeramalla ,  Srinivasa Rao Ravella ,  Ishtiyague Ahmad ,  Pradeep Jayarajan ,  Anil Karbhari Shinde ,  Rama Sastri Kambhampti ,  Gopinadh Bhyrapuneni ,  Venkateswarlu Jasti

发明人： Ramakrishna Nirogi ,  Abdul Rasheed Mohammed ,  Srinivas Veeramalla ,  Srinivasa Rao Ravella ,  Ishtiyague Ahmad ,  Pradeep Jayarajan ,  Anil Karbhari Shinde ,  Rama Sastri Kambhampti ,  Gopinadh Bhyrapuneni ,  Venkateswarlu Jasti

IPC分类号： C07D401/12

CPC分类号： C07D401/12

摘要： The present invention relates to novel bicyclic compounds of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. These compounds are useful in the treatment and prevention of various disorders that are related to α4β2 nicotinic receptors.

摘要翻译： 本发明涉及式（I）的新型双环化合物及其衍生物，前体药物，互变异构体，立体异构体，多晶型物，溶剂合物，水合物，代谢物，N-氧化物，药学上可接受的盐和含有它们的组合物。 本发明还涉及制备上述新化合物及其衍生物，前体药物，互变异构体，立体异构体，多晶型物，溶剂合物，水合物，代谢物，N-氧化物，药学上可接受的盐和含有它们的组合物的方法。 这些化合物可用于治疗和预防与α4和bgr2烟碱受体相关的各种疾病。

公开(公告)号：US08735423B2

公开(公告)日：2014-05-27

申请号：US13499998

申请日：2009-12-31

申请人： Ramakrishna Nirogi ,  Abdul Rasheed Mohammed ,  Srinivas Veeramalla ,  Srinivasa Rao Ravella ,  Ishtiyaque Ahmad ,  Pradeep Jayarajan ,  Anil Karbhari Shinde ,  Rama Sastri Kambhampti ,  Gopinadh Bhyrapuneni ,  Venkateswarlu Jasti

发明人： Ramakrishna Nirogi ,  Abdul Rasheed Mohammed ,  Srinivas Veeramalla ,  Srinivasa Rao Ravella ,  Ishtiyaque Ahmad ,  Pradeep Jayarajan ,  Anil Karbhari Shinde ,  Rama Sastri Kambhampti ,  Gopinadh Bhyrapuneni ,  Venkateswarlu Jasti

IPC分类号： C07D401/12 ,  A61K31/403

CPC分类号： C07D401/12

摘要： The present invention relates to novel bicyclic compounds of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. These compounds are useful in the treatment and prevention of various disorders that are related to α4β2 nicotinic receptors.

摘要翻译： 本发明涉及式（I）的新型双环化合物及其衍生物，前体药物，互变异构体，立体异构体，多晶型物，溶剂合物，水合物，代谢物，N-氧化物，药学上可接受的盐和含有它们的组合物。 本发明还涉及制备上述新化合物及其衍生物，前体药物，互变异构体，立体异构体，多晶型物，溶剂合物，水合物，代谢物，N-氧化物，药学上可接受的盐和含有它们的组合物的方法。 这些化合物可用于治疗和预防与α4和bgr2烟碱受体相关的各种疾病。