专利检索 ap:("Randall A. Roehl" OR "George W. Matcham" OR "David I. Stirling") AND inv:"Randall A. Roehl" 第 1 页

1.

发明授权
Process for the preparation of pyridine-2,3-dicarboxylic acids 失效
标题翻译：制备吡啶-2,3-二羧酸的方法

公开(公告)号：US5166060A

公开(公告)日：1992-11-24

申请号：US332339

申请日：1989-03-31

申请人： Randall A. Roehl , George W. Matcham , David I. Stirling

发明人： Randall A. Roehl , George W. Matcham , David I. Stirling

IPC分类号： C12P17/12 , C07D213/80 , C07D213/803 , C07D215/54 , C07D215/56 , C12N9/02 , C12N15/53 , C12P7/44 , C12R1/38

CPC分类号： C07D213/80 , C12N9/0069 , C12P7/44 , C12Y113/11014 , Y10S435/877

摘要： Pyridine-2,3-dicarboxylic acids are prepared by the action of 2,3-dihydroxybenzoate-3,4-dioxygenase on 2,3-dihydroxybenzoic acids in a liquid medium which lacks active decarboxylase and which has a pH from 4 to 9, an ionic strength below about 1 molar, and a low concentration of metal cations and complex anions. In close temporal proximity, the 2-hydroxy-3-carboxymuconic acid semialdehyde which forms is allowed to react with a source of ammonia or a primary amine, avoiding substantial decarboxylation.