公开(公告)号：US20140139204A1

公开(公告)日：2014-05-22

申请号：US14075557

申请日：2013-11-08

申请人： Rashid BASHIR ,  Bobby REDDY ,  Muhammad A ALAM ,  Pradeep R. NAIR ,  Jonghyun GO

发明人： Rashid BASHIR ,  Bobby REDDY ,  Muhammad A ALAM ,  Pradeep R. NAIR ,  Jonghyun GO

IPC分类号： G01R19/00

CPC分类号： G01N33/84 ,  C12Q1/25 ,  G01N27/414 ,  G01N33/5091 ,  G01N33/5438 ,  G01N33/573 ,  G01N33/574 ,  G01N33/94 ,  G01N2800/709

摘要： Provided herein are methods and devices for measuring pH and for amplifying a pH signal to obtain ultrasensitive detection of changes in pH. This is achieved by providing a sensor and a transducer, wherein the sensor transconductance is sensitive to changes in pH and the transducer transconductance is not affected by pH change. The transducer instead compensates for changes in the sensor transconductance arising from pH change. The unique configuration of the sensor and transducer with respect to each other provides substantial increases in a pH amplification factor, thereby providing pH sensing devices with a giant Nernst response and, therefore, effectively increased pH sensitivity.

摘要翻译： 本文提供了用于测量pH和用于扩增pH信号以获得pH变化的超灵敏检测的方法和装置。 这通过提供传感器和换能器来实现，其中传感器跨导对pH的变化敏感，并且换能器跨导不受pH变化的影响。 传感器代替补偿由pH变化引起的传感器跨导的变化。 传感器和换能器相对于彼此的独特配置提供了pH扩增因子的显着增加，由此提供具有巨能斯恩斯响应的pH感测装置，因此有效地增加了pH敏感性。