公开(公告)号：US08679459B2

公开(公告)日：2014-03-25

申请号：US12918238

申请日：2009-02-19

申请人： Ravindra K. Pandey ,  Chao Liu ,  Mahabeer Dobhal ,  William Potter ,  Janet Morgan ,  Stephanie Pincus

发明人： Ravindra K. Pandey ,  Chao Liu ,  Mahabeer Dobhal ,  William Potter ,  Janet Morgan ,  Allan Oseroff

IPC分类号： A61B5/055 ,  C07B47/00 ,  C07D487/22

CPC分类号： C07D487/22

摘要： Tetrapyrrolic photosensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95 percent and preferably have a fused system connected at an unsaturated carbon atom of the C ring nearest the D ring and at the unsaturated carbon atom between the C and D rings. The invention also includes a method of making the compounds at over 95 percent yield by starting with a B and D ring oxidized tetrapyrollic compound and dissolving it in a halogenated hydrocarbon solvent and treating it with sufficient nitroalkane solution of FeCl36H2O to oxidize the D ring and separating the resulting organic layer and drying.

摘要翻译： 具有A，B，C和D环的四吡咯类光敏剂和成像剂化合物，并具有还原的B环和氧化的D环。 化合物优选具有至少95％的纯度，并且优选具有在C环的最接近D环的不饱和碳原子和C和D环之间的不饱和碳原子连接的稠合体系。 本发明还包括通过用B和D环氧化的四元醇化合物开始制备化合物百分之九十五以上的方法，并将其溶解在卤代烃溶剂中，并用足够的FeCl 3·6H 2 O的硝基烷烃溶液处理以氧化D环并分离 所得有机层并干燥。

公开(公告)号：US20110264027A1

公开(公告)日：2011-10-27

申请号：US12918238

申请日：2009-02-19

申请人： Ravindra K. Pandey ,  Chao Liu ,  Mahabeer Dobhal ,  William Potter ,  Janet Morgan ,  Allan Oseroff ,  Stephanie Pincus

发明人： Ravindra K. Pandey ,  Chao Liu ,  Mahabeer Dobhal ,  William Potter ,  Janet Morgan ,  Allan Oseroff ,  Stephanie Pincus

IPC分类号： A61N5/00 ,  A61P35/00 ,  A61K51/04 ,  A61K49/00 ,  C07D487/22 ,  A61K49/04

CPC分类号： C07D487/22

摘要： Tetrapyrollic photosensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95 percent and preferably have a fused system connected at an unsaturated carbon atom of the C ring nearest the D ring and at the unsaturated carbon atom between the C and D rings. The invention also includes a method of making the compounds at over 95 percent yield by starting with a B and D ring oxidized tetrapyrollic compound and dissolving it in a halogenated hydrocarbon solvent and treating it with sufficient nitroalkane solution of FeCl3.6H2O to oxidize the D ring and separating the resulting organic layer and drying.

摘要翻译： 具有A，B，C和D环并且具有还原的B环和氧化的D环的四味光敏剂和显影剂化合物。 化合物优选具有至少95％的纯度，并且优选具有在C环的最接近D环的不饱和碳原子和C和D环之间的不饱和碳原子连接的稠合体系。 本发明还包括一种通过用B和D环氧化的四羰基化合物开始制备化合物超过95％的方法，并将其溶解在卤代烃溶剂中并用足量的FeCl 3·6H 2 O的硝基烷烃溶液处理以氧化D环 并分离得到的有机层并干燥。

公开(公告)号：US20080032939A1

公开(公告)日：2008-02-07

申请号：US11901113

申请日：2007-09-13

申请人： Ravindra Pandey ,  Mahabeer Dobhal ,  Andrew Graham ,  Allan Oseroff

发明人： Ravindra Pandey ,  Mahabeer Dobhal ,  Andrew Graham ,  Allan Oseroff

IPC分类号： A61K31/7048 ,  A61P35/00

CPC分类号： A61K31/7048

摘要： A method for treatment of hyperproliferative tissue which by exposing the hyperproliferative tissue to a sufficient quantity of a purified iridoid compound to inhibit its growth, where the iridoid compound includes a polysubstituted cyclopenta(c)dihydropyran where the cyclopenta ring is substituted at its 2′ position with a ketofuryl group, where the numbering of the fused cyclopenta(c)dihydropyran ring structure includes heterocyclic oxygen, is counterclockwise and begins at the first carbon atom counterclockwise from the cyclopenta ring so that oxygen is in the 2 position in the pyran ring. The invention also includes the mouse iridoid compounds.

摘要翻译： 一种用于治疗过度增殖组织的方法，其通过将过度增殖组织暴露于足量的纯化环烯醚萜类化合物以抑制其生长，其中环烯醚萜烯化合物包括多环取代的环戊二烯（c）二氢吡喃，其中环戊环在其2'位置被取代 其中稠合环戊二烯（c）二氢吡喃环结构的编号包括杂环氧的酮基呋喃基是逆时针方向，并且从环戊环逆时针开始于第一碳原子，使得氧在吡喃环中位于2位。 本发明还包括小鼠环烯醚萜类化合物。

公开(公告)号：US20050222053A1

公开(公告)日：2005-10-06

申请号：US10975312

申请日：2004-10-28

申请人： Ravindra Pandey ,  Mahabeer Dobhal ,  Andrew Graham ,  Allan Oseroff

发明人： Ravindra Pandey ,  Mahabeer Dobhal ,  Andrew Graham ,  Allan Oseroff

IPC分类号： A61K31/70 ,  A61K31/704 ,  A61K36/24 ,  C07H15/24

CPC分类号： A61K31/70 ,  A61K31/704 ,  A61K36/24 ,  C07H15/24

摘要： A method for treatment of hyperproliferative tissue which by exposing the hyperproliferative tissue to a sufficient quantity of a purified iridoid compound to inhibit its growth, where the iridoid compound includes a polysubstituted cyclopenta(c)dihydropyran where the cyclopenta ring is substituted at its 2′ position with a ketofuryl group, where the numbering of the fused cyclopenta(c)dihydropyran ring structure includes heterocyclic oxygen, is counterclockwise and begins at the first carbon atom counterclockwise from the cyclopenta ring so that oxygen is in the 2 position in the pyran ring. The invention also includes the mouse iridoid compounds.

摘要翻译： 一种用于治疗过度增殖组织的方法，其通过将过度增殖组织暴露于足量的纯化环烯醚萜类化合物以抑制其生长，其中环烯醚萜烯化合物包括多环取代的环戊二烯（c）二氢吡喃，其中环戊环在其2'位置被取代 其中稠合环戊二烯（c）二氢吡喃环结构的编号包括杂环氧的酮基呋喃基是逆时针方向，并且从环戊环逆时针开始于第一碳原子，使得氧在吡喃环中位于2位。 本发明还包括小鼠环烯醚萜类化合物。