公开(公告)号：US20070099239A1

公开(公告)日：2007-05-03

申请号：US11473826

申请日：2006-06-23

申请人： Raymond Tabibiazar ,  Philip Tsao ,  Thomas Quertermous ,  Brit Turnbull ,  Richard Olshen ,  Evangelos Hytopoulos

发明人： Raymond Tabibiazar ,  Philip Tsao ,  Thomas Quertermous ,  Brit Turnbull ,  Richard Olshen ,  Evangelos Hytopoulos

IPC分类号： G01N33/53 ,  G06F19/00

CPC分类号： G01N33/6893 ,  G01N2800/60 ,  G16B40/00 ,  Y02A90/24 ,  Y02A90/26

摘要： The present invention identifies circulating proteins that are differentially expressed in atherosclerosis. Circulating levels of these proteins, particularly as a panel of proteins, can discriminate patients with acute myocardial infarction from those with stable exertional angina and from those with no history of atherosclerotic cardiovascular disease. Such levels can also predict cardiovascular events, determine the effectiveness of therapy, stage disease, and the like. For example, these markers are useful as surrogate biomarkers of clinical events needed for development of vascular specific pharmaceutical agents.

摘要翻译： 本发明鉴定在动脉粥样硬化中差异表达的循环蛋白质。 这些蛋白质的循环水平，特别是作为一组蛋白质，可以将急性心肌梗死患者与具有稳定的劳力性心绞痛的患者以及没有动脉粥样硬化性心血管疾病史的患者区分开来。 这些水平也可以预测心血管事件，确定治疗的有效性，疾病阶段等。 例如，这些标记物可用作开发血管特异性药剂所需的临床事件的替代生物标志物。