公开(公告)号：US08053458B2

公开(公告)日：2011-11-08

申请号：US11855521

申请日：2007-09-14

申请人： Raymond W. Kosley ,  Douglas MacDonald ,  Rosy Sher

发明人： Raymond W. Kosley ,  Douglas MacDonald ,  Rosy Sher

IPC分类号： A61K31/455 ,  C07D231/26

CPC分类号： C07D401/14 ,  C07D231/22 ,  C07D231/26

摘要： The present invention is directed to dipyrazole compounds of formula I and their pharmaceutically acceptable salts, stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula I. The compounds of this invention modulate AMPA and NMDA receptor function, and therefore are useful as pharmaceutical agents, especially for the treatment of neuropsychiatric disorders.

摘要翻译： 本发明涉及式I的二吡唑化合物及其药学上可接受的盐，立体异构体，互变异构体或溶剂化物。 新型化合物包括式I化合物。本发明化合物调节AMPA和NMDA受体功能，因此可用作药剂，特别是用于治疗神经精神障碍。