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公开(公告)号：US20210188934A1
公开(公告)日：2021-06-24
申请号：US17127359
申请日：2020-12-18
发明人： Jiaxi WU , Tong ZHANG , Maria del Pilar MOLINA-PORTELA , Eric SMITH , Chia-Yang LIN , Thomas Craig Meagher
IPC分类号： C07K14/55 , C07K14/715 , A61K47/68 , A61P35/00
摘要： The present disclosure relates to IL2 agonists with improved therapeutic profiles.
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公开(公告)号：US20210187027A1
公开(公告)日：2021-06-24
申请号：US17127380
申请日：2020-12-18
发明人： Jiaxi WU , Tong ZHANG , Maria del Pilar MOLINA-PORTELA , Eric SMITH , Chia-Yang LIN , Thomas Craig MEAGHER
摘要： The present disclosure relates to IL2 agonists with improved therapeutic profiles.
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公开(公告)号：US20240309072A1
公开(公告)日：2024-09-19
申请号：US18589384
申请日：2024-02-27
发明人： Nianshuang WANG , Yang SHEN , Alina BAUM , Christos KYRATSOUS , Chia-Yang LIN
CPC分类号： C07K16/1003 , A61P31/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/622
摘要： The present disclosure provides multivalent anti-spike protein binding molecules, comprising multimerization moieties linked to anti-spike protein antigen-binding domains, that specifically bind to RBD regions of SARS-COV and/or SARS-COV-2. The present disclosure further relates to the methods of producing the multivalent anti-spike protein binding molecules, pharmaceutical compositions comprising of the multivalent anti-spike protein binding molecules, and methods of use of the multivalent anti-spike protein binding molecules to treat conditions associated with SARS-COV and SARS-COV-2 infections, such as COVID-19.
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公开(公告)号：US20220362395A1
公开(公告)日：2022-11-17
申请号：US17843243
申请日：2022-06-17
发明人： Jiaxi WU , Tong ZHANG , Maria del Pilar MOLINA-PORTELA , Eric Smith , Chia-Yang LIN , Thomas Craig Meagher
摘要： The present disclosure relates to IL2 agonists with improved therapeutic profiles.
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公开(公告)号：US20210130477A1
公开(公告)日：2021-05-06
申请号：US17088918
申请日：2020-11-04
发明人： Yang SHEN , Ann-Hwee LEE , Yan YANG , Chia-Yang LIN
摘要： Multispecific binding molecules (MBMs) comprising an N-terminal scFv, a first Fab and a second Fab, MBM conjugates comprising the MBMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the MBMs and MBM conjugates, methods of using the MBMs, MBM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the MBMs, cells engineered to express the MBMs, and methods of producing MBMs.
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公开(公告)号：US20240307512A1
公开(公告)日：2024-09-19
申请号：US18588774
申请日：2024-02-27
发明人： Nianshuang WANG , Yang SHEN , Alina BAUM , Christos KYRATSOUS , Chia-Yang LIN
CPC分类号： A61K38/4813 , A61P31/14 , C12N9/485 , C12Y304/17023
摘要： The present disclosure provides ACE2 fusion proteins, comprising multimerization moieties linked to ACE2 moieties, that specifically bind to RBD regions of SARS-COV and/or SARS-COV-2. The present disclosure further relates to the methods of producing the ACE2 fusion proteins, pharmaceutical compositions comprising of the ACE2 fusion proteins, and methods of use of the ACE2 fusion proteins to treat conditions associated with SARS-COV and SARS-COV-2 infections, such as COVID-19.
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公开(公告)号：US20240067691A1
公开(公告)日：2024-02-29
申请号：US18451797
申请日：2023-08-17
发明人： Eva-Maria WEICK , Nicolin BLOCH , Vidur GARG , Erica ULLMAN , Tong ZHANG , Chia-Yang LIN , Jiaxi WU , Eric Smith
IPC分类号： C07K14/56 , C07K14/715
CPC分类号： C07K14/56 , C07K14/7156 , A61K38/00 , C07K2319/30
摘要： The present disclosure provides interferon receptor agonists with improved safety profiles and therapeutic indices. The interferon receptor agonists are attenuated through masking and/or reduced receptor binding as compared to a wild-type interferon. IFN receptor agonists optionally further comprise a targeting moiety, e.g., a targeting moiety that recognizes a tumor- or immune cell-associated antigen and directs the interferon receptor agonist to a tumor site and/or tumor-reactive immune cells. The disclosure further provides pharmaceutical compositions comprising the interferon receptor agonists, and methods of use of the interferon receptor agonists in therapy, as well as nucleic acids encoding the interferon receptor agonists, recombinant cells that express the interferon receptor agonists and methods of producing the interferon receptor agonists.
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公开(公告)号：US20230331800A1
公开(公告)日：2023-10-19
申请号：US18314205
申请日：2023-05-09
发明人： Jiaxi WU , Tong ZHANG , Maria del Pilar MOLINA-PORTELA , Eric SMITH , Chia-Yang LIN , Thomas Craig MEAGHER
IPC分类号： C07K14/55 , A61K47/68 , A61P35/00 , C07K14/715 , A61K35/17 , C07K14/74 , A61K38/20 , C07K14/725 , C07K14/705
CPC分类号： C07K14/55 , A61K47/6849 , A61P35/00 , C07K14/7155 , A61K35/17 , C07K14/70539 , A61K38/2013 , C07K14/7051 , C07K14/70517 , A61K38/00
摘要： The present disclosure relates to IL2 agonists with improved therapeutic profiles.
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公开(公告)号：US20230279153A1
公开(公告)日：2023-09-07
申请号：US18053868
申请日：2022-11-09
发明人： Yang SHEN , Bei WANG , Naga Suhasini AVVARU , Chia-Yang LIN , Andrew MURPHY , Aynur HERMANN , Jee H. KIM
CPC分类号： C07K16/468 , A61P3/10 , C07K2317/55 , C07K2317/52 , C07K2317/31
摘要： The present disclosure relates to molecules capable of binding to both CD20 and PD1, as well as pharmaceutical compositions comprising such molecules and methods of use thereof.
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公开(公告)号：US20220251220A1
公开(公告)日：2022-08-11
申请号：US17726950
申请日：2022-04-22
发明人： Yang SHEN , Ann-Hwee LEE , Yan YANG , Chia-Yang LIN
IPC分类号： C07K16/28
摘要： Multispecific binding molecules (MBMs) comprising an N-terminal scFv, a first Fab and a second Fab, MBM conjugates comprising the MBMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the MBMs and MBM conjugates, methods of using the MBMs, MBM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the MBMs, cells engineered to express the MBMs, and methods of producing MBMs.
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