公开(公告)号：US20250043017A1

公开(公告)日：2025-02-06

申请号：US18766802

申请日：2024-07-09

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Saida Dadi-Mehmetaj ,  Lauric Haber ,  Jessica Kirshner ,  Lauren Canova-Kleinman ,  Erica Ullman

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

Abstract: The present disclosure provides bispecific antigen-binding molecules that bind to PD-L1 and 4-1BB (PD-L1×4-1BB). In certain embodiments, the present disclosure provides a bispecific PD-L1×4-1BB antibody or antigen-binding fragment thereof comprising a first antigen-binding domain that specifically binds 4-1BB, and a second antigen-binding domain that specifically binds PD-L1. In certain embodiments, the bispecific antibodies disclosed herein bind 4-1BB on T-cells with the first antigen-binding domain and PD-L1 expressed on tumor cells or antigen presenting cells with the second antigen-binding domain. In certain embodiments, the antibodies of the present disclosure are useful in treatment of a cancer.

公开(公告)号：US20250043002A1

公开(公告)日：2025-02-06

申请号：US18766785

申请日：2024-07-09

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Saida Dadi-Mehmetaj ,  Lauric Haber ,  Jessica Kirshner ,  Lauren Canova-Kleinman ,  Erica Ullman

IPC: C07K16/28 ,  A61K39/00 ,  A61K45/06 ,  A61P35/00 ,  C12N15/85

Abstract: The present disclosure provides bispecific antigen-binding molecules that bind to PD-L1 and CD28 (PD-L1×CD28). In certain embodiments, the present disclosure provides for a bispecific PD-L1×CD28 antigen-binding molecule (or antibody) or antigen-binding fragment thereof comprising a first antigen-binding domain that specifically binds CD28, and a second antigen-binding domain that specifically binds PD-L1. In certain embodiments, the bispecific antigen-binding molecules of the present disclosure bind CD28 on T-cells with the first antigen-binding domain and PD-L1 expressed on tumor cells or antigen presenting cells with the second antigen-binding domain. In certain embodiments, the bispecific antigen-binding molecules are capable of inhibiting growth of a tumor. The bispecific antigen-binding molecules of this disclosure are useful for treatment of cancer.