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公开(公告)号：US11834485B2
公开(公告)日：2023-12-05
申请号：US17234896
申请日：2021-04-20
发明人： Jiaxi Wu , Tong Zhang , Samuel Davis , Nicolin Bloch
CPC分类号： C07K14/55 , A61K38/2013 , A61K45/06 , C07K14/4748 , C07K14/70535 , C07K14/70539 , A61K38/00 , C07K2319/21 , C07K2319/30 , C07K2319/33 , C07K2319/41
摘要： This disclosure relates to IL-2 variants and methods of use thereof, including methods of treating or inhibiting a cancer or tumor. The IL-2 variants may have reduced ability in binding to or activating IL-2Rα. The IL-2 variants may retain the ability in binding to or activating IL-2Rβ and/or IL-2Rβγ. In addition, the IL-2 variants may have decreased Treg activity but maintain the capacity to activate NK cells and T effector cells.
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公开(公告)号：US20230340105A1
公开(公告)日：2023-10-26
申请号：US18318871
申请日：2023-05-17
发明人： Tong Zhang , Erica Pyles , Michael Rosconi , Nina Liu , Supriya Patel , Eric Smith , Andrew Murphy , Chia-Yang Lin , Samuel Davis
IPC分类号： A61K39/395 , C07K16/28 , C07K16/24 , A61K47/68 , C07K16/30
CPC分类号： C07K16/244 , A61K39/395 , A61K47/6845 , C07K16/2809 , C07K16/30 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/53 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
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公开(公告)号：US20220235126A1
公开(公告)日：2022-07-28
申请号：US17666107
申请日：2022-02-07
发明人： Tong Zhang , Erica Pyles , Michael Rosconi , Nina Liu , Supriya Patel , Eric Smith , Andrew Murphy , Chiayang Lin , Samuel Davis
摘要： Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
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公开(公告)号：US20230287117A1
公开(公告)日：2023-09-14
申请号：US17961442
申请日：2022-10-06
发明人： Samuel Davis , Eric Smith , Tong Zhang , Supriya Patel
IPC分类号： C07K16/28
CPC分类号： C07K16/2809 , C07K16/2803 , C07K16/2887 , C07K2317/24 , C07K2317/31 , C07K2317/526 , C07K2317/53 , C07K2317/71 , C07K2317/732 , C07K2317/90
摘要： The invention provides antibody heavy chain constant regions with a hinge region modified to reduce binding to Fcy receptors. The modification occurs within positions 233-236 by replacement of natural residues by glycine(s) and/or deletion(s). Such modifications can reduce binding of an antibody bearing such a constant region to Fcy receptors to background levels. The constant regions can be incorporated into any format of antibody or Fc fusion protein. Such antibodies or fusion proteins can be used in methods of treatment, particularly those in which the mechanisms of action of the antibody or Fc fusion protein is not primarily or at all dependent on effector functions, as is the case when an antibody inhibits a receptor-ligand interaction or agonizes a receptor.
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公开(公告)号：US12091440B2
公开(公告)日：2024-09-17
申请号：US17127380
申请日：2020-12-18
发明人： Jiaxi Wu , Tong Zhang , Maria del Pilar Molina-Portela , Eric Smith , Chia-Yang Lin , Thomas Craig Meagher
IPC分类号： C07K14/55 , A61K35/17 , A61K38/00 , A61K38/20 , A61K47/68 , A61P35/00 , C07K14/705 , C07K14/715 , C07K14/725 , C07K14/74
CPC分类号： C07K14/55 , A61K35/17 , A61K38/2013 , A61K47/6849 , A61P35/00 , C07K14/7051 , C07K14/70517 , C07K14/70539 , C07K14/7155 , A61K38/00 , C07K2319/30
摘要： The present disclosure relates to IL2 agonists with improved therapeutic profiles.
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公开(公告)号：US20240294627A1
公开(公告)日：2024-09-05
申请号：US18640981
申请日：2024-04-19
发明人： Tong Zhang , Erica Pyles , Michael Rosconi , Nina Liu , Supriya Patel , Eric Smith , Andrew Murphy , Chia-Yang Lin , Samuel Davis
IPC分类号： C07K16/24 , A61K39/395 , A61K47/68 , C07K16/28 , C07K16/30
CPC分类号： C07K16/244 , A61K39/395 , A61K47/6845 , C07K16/2809 , C07K16/30 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/53 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
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公开(公告)号：US20210324030A1
公开(公告)日：2021-10-21
申请号：US17234896
申请日：2021-04-20
发明人： Jiaxi Wu , Tong Zhang , Samuel Davis , Nicolin Bloch
摘要： This disclosure relates to IL-2 variants and methods of use thereof, including methods of treating or inhibiting a cancer or tumor. The IL-2 variants may have reduced ability in binding to or activating IL-2Rα. The IL-2 variants may retain the ability in binding to or activating IL-2Rβ and/or IL-2Rβγ. In addition, the IL-2 variants may have decreased Treg activity but maintain the capacity to activate NK cells and T effector cells.
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公开(公告)号：US11965020B2
公开(公告)日：2024-04-23
申请号：US18318871
申请日：2023-05-17
发明人： Tong Zhang , Erica Pyles , Michael Rosconi , Nina Liu , Supriya Patel , Eric Smith , Andrew Murphy , Chia-Yang Lin , Samuel Davis
IPC分类号： C07K16/24 , A61K39/395 , A61K47/68 , C07K16/28 , C07K16/30
CPC分类号： C07K16/244 , A61K39/395 , A61K47/6845 , C07K16/2809 , C07K16/30 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/53 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
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公开(公告)号：US11708407B2
公开(公告)日：2023-07-25
申请号：US17666116
申请日：2022-02-07
发明人： Tong Zhang , Erica Pyles , Michael Rosconi , Nina Liu , Supriya Patel , Eric Smith , Andrew Murphy , Chia-Yang Lin , Samuel Davis
IPC分类号： C07K16/24 , C07K16/28 , C07K16/30 , A61K47/68 , A61K39/395
CPC分类号： C07K16/244 , A61K39/395 , A61K47/6845 , C07K16/2809 , C07K16/30 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/53 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
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公开(公告)号：US20220402989A1
公开(公告)日：2022-12-22
申请号：US17806566
申请日：2022-06-13
发明人： Jiaxi Wu , Nicolin Bloch , Tong Zhang , Chia-Yang Lin , Samuel Davis , Eric Smith , Erica Ullman
IPC分类号： C07K14/55 , C07K16/28 , C07K14/715 , A61P35/00
摘要： The present disclosure relates to a fusion protein comprising an antigen-binding moiety that binds specifically to human PD-1 and an IL2 moiety, and methods of use thereof.
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