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公开(公告)号：US20120027766A1
公开(公告)日：2012-02-02
申请号：US13262634
申请日：2010-04-01
申请人： Reginald Christophe Xavier Brys , Luc Nelles , Nick Ernest Rene Vandeghinste , Blandine Mille-Baker , Michela Angela Tessari
发明人： Reginald Christophe Xavier Brys , Luc Nelles , Nick Ernest Rene Vandeghinste , Blandine Mille-Baker , Michela Angela Tessari
IPC分类号： A61K39/395 , A61K31/711 , A61K38/00 , C40B30/04 , A61K31/7105
CPC分类号： C12N15/1137 , C12N15/113 , C12N15/1138 , C12N2310/14 , G01N33/5032 , G01N33/6887 , G01N2333/726 , G01N2333/912 , G01N2333/9121 , G01N2333/96486 , G01N2333/96494 , G01N2500/04 , G01N2500/10 , G01N2500/20 , G01N2800/105
摘要： The invention relates to the field of medicinal research, cartilage physiology and diseases involving the degeneration of cartilage tissue. More specifically, the invention relates to methods and means for identifying compounds that inhibit catabolic processes in chondrocytes and that decrease the degradation of cartilage and/or ECM. The invention also relates to the compounds that are useful in the treatment of osteoarthritis. The invention also relates to targets, the modulation of which results in a decrease in the degradation of ECM and/or cartilage and decrease inflammation. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by the degradation of ECM and/or cartilage and inflammation.
摘要翻译： 本发明涉及药物研究，软骨生理学和涉及软骨组织退化的疾病领域。 更具体地，本发明涉及用于鉴定抑制软骨细胞分解代谢过程并降低软骨和/或ECM降解的化合物的方法和手段。 本发明还涉及可用于治疗骨关节炎的化合物。 本发明还涉及靶的调节，其导致ECM和/或软骨的降解降低并减少炎症。 此外，本发明涉及用于治疗以ECM和/或软骨和炎症降解为特征的病症的组合物和方法。
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公开(公告)号：US20140200258A1
公开(公告)日：2014-07-17
申请号：US14162908
申请日：2014-01-24
申请人： Reginald Christophe Xavier Brys , Luc Nelles , Nick Ernest Rene Vandeghinste , Blandine Mille-Baker , Michela Angela Tessari
发明人： Reginald Christophe Xavier Brys , Luc Nelles , Nick Ernest Rene Vandeghinste , Blandine Mille-Baker , Michela Angela Tessari
IPC分类号： G01N33/50 , C12N15/113
CPC分类号： C12N15/1137 , C12N15/113 , C12N15/1138 , C12N2310/14 , G01N33/5032 , G01N33/6887 , G01N2333/726 , G01N2333/912 , G01N2333/9121 , G01N2333/96486 , G01N2333/96494 , G01N2500/04 , G01N2500/10 , G01N2500/20 , G01N2800/105
摘要： The invention relates to the field of medicinal research, cartilage physiology and diseases involving the degeneration of cartilage tissue. More specifically, the invention relates to methods and means for identifying compounds that inhibit catabolic processes in chondrocytes and that decrease the degradation of cartilage and/or ECM. The invention also relates to the compounds that are useful in the treatment of osteoarthritis. The invention also relates to targets, the modulation of which results in a decrease in the degradation of ECM and/or cartilage and decrease inflammation. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by the degradation of ECM and/or cartilage and inflammation.
摘要翻译： 本发明涉及药物研究，软骨生理学和涉及软骨组织退化的疾病领域。 更具体地，本发明涉及用于鉴定抑制软骨细胞分解代谢过程并降低软骨和/或ECM降解的化合物的方法和手段。 本发明还涉及可用于治疗骨关节炎的化合物。 本发明还涉及靶的调节，其导致ECM和/或软骨的降解降低并减少炎症。 此外，本发明涉及用于治疗以ECM和/或软骨和炎症降解为特征的病症的组合物和方法。
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公开(公告)号：US08663930B2
公开(公告)日：2014-03-04
申请号：US13262634
申请日：2010-04-01
申请人： Reginald Christophe Xavier Brys , Luc Nelles , Nick Ernest Rene Vandeghinste , Blandine Mille-Baker , Michela Angela Tessari
发明人： Reginald Christophe Xavier Brys , Luc Nelles , Nick Ernest Rene Vandeghinste , Blandine Mille-Baker , Michela Angela Tessari
IPC分类号： G01N33/53
CPC分类号： C12N15/1137 , C12N15/113 , C12N15/1138 , C12N2310/14 , G01N33/5032 , G01N33/6887 , G01N2333/726 , G01N2333/912 , G01N2333/9121 , G01N2333/96486 , G01N2333/96494 , G01N2500/04 , G01N2500/10 , G01N2500/20 , G01N2800/105
摘要： The invention relates to the field of medicinal research, cartilage physiology and diseases involving the degeneration of cartilage tissue. More specifically, the invention relates to methods and means for identifying compounds that inhibit catabolic processes in chondrocytes and that decrease the degradation of cartilage and/or ECM. The invention also relates to the compounds that are useful in the treatment of osteoarthritis. The invention also relates to targets, the modulation of which results in a decrease in the degradation of ECM and/or cartilage and decrease inflammation. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by the degradation of ECM and/or cartilage and inflammation.
摘要翻译： 本发明涉及药物研究，软骨生理学和涉及软骨组织退化的疾病领域。 更具体地，本发明涉及用于鉴定抑制软骨细胞分解代谢过程并降低软骨和/或ECM降解的化合物的方法和手段。 本发明还涉及可用于治疗骨关节炎的化合物。 本发明还涉及靶的调节，其导致ECM和/或软骨的降解降低并减少炎症。 此外，本发明涉及用于治疗以ECM和/或软骨和炎症降解为特征的病症的组合物和方法。
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公开(公告)号：US20160208266A1
公开(公告)日：2016-07-21
申请号：US15014290
申请日：2016-02-03
申请人： Reginald Christophe Xavier Brys , Luc Nelles , Nick Ernest Rene Vandeghinste , Blandine Mille-Baker , Michela Angela Tessari
发明人： Reginald Christophe Xavier Brys , Luc Nelles , Nick Ernest Rene Vandeghinste , Blandine Mille-Baker , Michela Angela Tessari
IPC分类号： C12N15/113 , G01N33/68 , G01N33/50
CPC分类号： C12N15/1137 , C12N15/113 , C12N15/1138 , C12N2310/14 , G01N33/5032 , G01N33/6887 , G01N2333/726 , G01N2333/912 , G01N2333/9121 , G01N2333/96486 , G01N2333/96494 , G01N2500/04 , G01N2500/10 , G01N2500/20 , G01N2800/105
摘要： The invention relates to the field of medicinal research, cartilage physiology and diseases involving the degeneration of cartilage tissue. More specifically, the invention relates to methods and means for identifying compounds that inhibit catabolic processes in chondrocytes and that decrease the degradation of cartilage and/or ECM. The invention also relates to the compounds that are useful in the treatment of osteoarthritis. The invention also relates to targets, the modulation of which results in a decrease in the degradation of ECM and/or cartilage and decrease inflammation. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by the degradation of ECM and/or cartilage and inflammation.
摘要翻译： 本发明涉及药物研究，软骨生理学和涉及软骨组织退化的疾病领域。 更具体地，本发明涉及用于鉴定抑制软骨细胞分解代谢过程并降低软骨和/或ECM降解的化合物的方法和手段。 本发明还涉及可用于治疗骨关节炎的化合物。 本发明还涉及靶的调节，其导致ECM和/或软骨的降解降低并减少炎症。 此外，本发明涉及用于治疗以ECM和/或软骨和炎症降解为特征的病症的组合物和方法。
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5.发明申请Molecular targets and compounds, and methods to identify the same, useful in the treatment of bone and joint degenerative diseases 失效分子靶标和化合物以及鉴别方法相同，可用于治疗骨关节退行性疾病公开(公告)号：US20090117107A1
公开(公告)日：2009-05-07
申请号：US12214787
申请日：2008-06-19
IPC分类号： A61K39/395 , G01N33/566 , C40B30/04 , C07H21/04 , C07H21/02 , A61P19/10 , C12N15/869 , A61K31/711 , C12N15/86 , C12N15/867 , A61P19/00 , C12N15/861 , A61K31/7105 , A61K35/76
CPC分类号： G01N33/5308 , A61K31/7088 , A61K31/713 , A61K45/06 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/12 , C12Y111/01006 , G01N33/6887 , G01N2500/04 , G01N2800/102 , G01N2800/105
摘要： The present invention relates to methods for identifying agents capable of inhibiting the expression or activity of proteins involved in the processes modulating osteoclastogenesis, which inhibition is useful in the prevention and/or treatment of bone and joint degenerative diseases and diseases involving aberrant activity or differentiation of osteoclasts. In particular, the present invention provides methods for identifying agents for use in the prevention and/or treatment of rheumatoid arthritis.
摘要翻译： 本发明涉及用于鉴定能够抑制参与调节破骨细胞发生过程的蛋白质的表达或活性的试剂的方法，所述抑制剂可用于预防和/或治疗骨和关节变性疾病和涉及异常活动或分化的疾病 破骨细胞。 特别地，本发明提供用于鉴定用于预防和/或治疗类风湿性关节炎的药剂的方法。
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6.发明申请MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF BONE AND JOINT DEGENERATIVE DISEASES 审中-公开分子靶向化合物及其鉴别方法，有助于治疗骨质疏松性疾病公开(公告)号：US20140155461A1
公开(公告)日：2014-06-05
申请号：US14106951
申请日：2013-12-16
IPC分类号： G01N33/53 , A61K31/7088 , A61K45/06 , A61K31/713
CPC分类号： G01N33/5308 , A61K31/7088 , A61K31/713 , A61K45/06 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/12 , C12Y111/01006 , G01N33/6887 , G01N2500/04 , G01N2800/102 , G01N2800/105
摘要： The present invention relates to methods for identifying agents capable of inhibiting the expression or activity of proteins involved in the processes modulating osteoclastogenesis, which inhibition is useful in the prevention and/or treatment of bone and joint degenerative diseases and diseases involving aberrant activity or differentiation of osteoclasts. In particular, the present invention provides methods for identifying agents for use in the prevention and/or treatment of rheumatoid arthritis.
摘要翻译： 本发明涉及用于鉴定能够抑制参与调节破骨细胞发生过程的蛋白质的表达或活性的试剂的方法，所述抑制剂可用于预防和/或治疗骨和关节变性疾病和涉及异常活动或分化的疾病 破骨细胞。 特别地，本发明提供用于鉴定用于预防和/或治疗类风湿性关节炎的药剂的方法。
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