公开(公告)号：US20200253969A1

公开(公告)日：2020-08-13

申请号：US16651733

申请日：2018-09-28

Applicant: Relay Therapeutics, Inc. ,  D.E. Shaw Research, LLC

Inventor： Alexander M. Taylor ,  W. Patrick Walters ,  Mark Andrew Murcko ,  Fabrizio Giordanetto ,  Eric Therrien ,  Sathesh Bhat ,  Markus Kristofer Dahlgren

IPC: A61K31/4985 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00

Abstract: Disclosed herein are novel compounds of formula (I) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds ad compositions of the disclosure.

公开(公告)号：US20220315586A1

公开(公告)日：2022-10-06

申请号：US16982401

申请日：2019-03-21

Applicant: Relay Therapeutics, Inc. ,  D.E. Shaw Research, LLC

Inventor： Alexander M. Taylor ,  André Lescarbeau ,  Elizabeth H. Kelley ,  Kelley C. Shortsleeves ,  W. Patrick Walters ,  Mark Andrew Murcko ,  Thomas H. McLean ,  Hakan Gunaydin ,  Fabrizio Giordanetto ,  Eric Therrien

IPC: C07D487/04 ,  C07D519/00 ,  C07D401/04 ,  C07D401/14 ,  C07D491/107 ,  C07D513/04 ,  C07D417/04 ,  C07D417/14 ,  C07D221/20 ,  C07D401/12

Abstract: The present disclosure relates to novel compounds including formula (X) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

公开(公告)号：US20200172546A1

公开(公告)日：2020-06-04

申请号：US16616361

申请日：2018-05-25

Applicant: Relay Therapeutics, Inc. ,  D.E. Shaw Research, LLC

Inventor： Alexander M. Taylor ,  André Lescarbeau ,  Elizabeth H. Kelley ,  Kelley C. Shortsleeves ,  Lucian V. DiPietro ,  W. Patrick Walters ,  Mark Andrew Murcko ,  Levi Charles Thomas Pierce ,  Yong Tang ,  Fabrizio Giordanetto ,  Jack Benjamin Greisman ,  Paul Maragakis ,  Sathesh Bhat ,  Markus Kristofer Dahlgren ,  Eric Therrien

IPC: C07D487/04 ,  C07D519/00

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure

公开(公告)号：US20200062760A1

公开(公告)日：2020-02-27

申请号：US16344061

申请日：2017-10-24

Applicant: Relay Therapeutics, Inc. ,  D.E. Shaw Research, LLC

Inventor： Fabrizio Giordanetto ,  Jack Benjamin Greisman ,  Paul Maragakis ,  Alexander M. Taylor ,  Lucian V. Dipietro ,  Elizabeth H. Kelley ,  André Lescarbeau ,  Mark Andrew Murcko ,  Levi Charles Thomas Pierce ,  Kelley C. Shortsleeves ,  W. Patrick Walters ,  Sathesh Bhat ,  Eric Therrien ,  Markus Kristofer Dahlgren

IPC: C07D487/04 ,  C07D519/00

Abstract: The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the invention. The present invention further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds ad compositions of the invention.

公开(公告)号：US20220340576A1

公开(公告)日：2022-10-27

申请号：US16950576

申请日：2020-11-17

Applicant: Relay Therapeutics, Inc. ,  D. E. Shaw Research, LLC

Inventor： Alexander M. Taylor ,  André Lescarbeau ,  Elizabeth H. Kelley ,  Kelley C. Shortsleeves ,  W. Patrick Walters ,  Mark Andrew Murcko ,  Thomas H. McLean ,  Hakan Gunaydin ,  Fabrizio Giordanetto ,  Eric Therrien

IPC: C07D487/04 ,  C07D401/04 ,  C07D401/14 ,  C07D519/00

Abstract: The present disclosure relates to novel compounds including formula (X) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

公开(公告)号：US20230234958A1

公开(公告)日：2023-07-27

申请号：US18066551

申请日：2022-12-15

Applicant: Relay Therapeutics, Inc. ,  D. E. Shaw Research, LLC.

Inventor： Alexander M. Taylor ,  Andre Lescarbbeau ,  Elizabeth H. Kelley ,  Kelley C. Shortsleeves ,  W. Patrick Walters ,  Mark Andrew Murcko ,  Thomas H. McLean ,  Hakan Gunaydin ,  Fabrizio Giordanetto ,  Eric Therrien

IPC: C07D487/04 ,  C07D401/04 ,  C07D401/14 ,  C07D519/00 ,  C07D221/20 ,  C07D401/12 ,  C07D417/04 ,  C07D417/14 ,  C07D491/107 ,  C07D513/04

CPC classification number: C07D487/04 ,  C07D401/04 ,  C07D401/14 ,  C07D519/00 ,  C07D221/20 ,  C07D401/12 ,  C07D417/04 ,  C07D417/14 ,  C07D491/107 ,  C07D513/04

Abstract: The present disclosure relates to novel compounds including formula (X) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

公开(公告)号：US12084447B2

公开(公告)日：2024-09-10

申请号：US16950576

申请日：2020-11-17

Applicant: Relay Therapeutics, Inc. ,  D. E. Shaw Research, LLC

Inventor： Alexander M. Taylor ,  André Lescarbeau ,  Elizabeth H. Kelley ,  Kelley C. Shortsleeves ,  W. Patrick Walters ,  Mark Andrew Murcko ,  Thomas H. McLean ,  Hakan Gunaydin ,  Fabrizio Giordanetto ,  Eric Therrien

IPC: C07D487/04 ,  C07D221/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D417/04 ,  C07D417/14 ,  C07D491/107 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D221/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D417/04 ,  C07D417/14 ,  C07D491/107 ,  C07D513/04 ,  C07D519/00

Abstract: The present disclosure relates to novel compounds including formula (X) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

公开(公告)号：US11701354B2

公开(公告)日：2023-07-18

申请号：US16651733

申请日：2018-09-28

Applicant: Relay Therapeutics, Inc. ,  D. E. Shaw Research, LLC

Inventor： Alexander M. Taylor ,  W. Patrick Walters ,  Mark Andrew Murcko ,  Fabrizio Giordanetto ,  Eric Therrien ,  Sathesh Bhat ,  Markus Kristofer Dahlgren

IPC: A61K31/4985 ,  C07D487/04 ,  A61K45/06 ,  C07D519/00

CPC classification number: A61K31/4985 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00

Abstract: Cellular biological activities are tightly controlled by intracellular signaling processes initiated by extracellular signals. Protein tyrosine phosphatases, which remove phosphate groups from tyrosine phosphorylated signaling molecules, play equally important tyrosine roles as protein kinases in signal transduction. SHP-2, a cytoplasmic SH2 domain containing protein tyrosine phosphatase, is involved in the signaling pathways of a variety of growth factors and cytokines. Recent studies have clearly demonstrated that this phosphatase plays an important role in transducing signal relay from the cell surface to the nucleus, and is a critical intracellular regulator in mediating cell proliferation and differentiation.

公开(公告)号：US11591336B2

公开(公告)日：2023-02-28

申请号：US16616361

申请日：2018-05-25

Applicant: Relay Therapeutics, Inc. ,  D. E. Shaw Research, LLC

Inventor： Alexander M. Taylor ,  André Lescarbeau ,  Elizabeth H. Kelley ,  Kelley C. Shortsleeves ,  Lucian V. DiPietro ,  W. Patrick Walters ,  Mark Andrew Murcko ,  Levi Charles Thomas Pierce ,  Yong Tang ,  Fabrizio Giordanetto ,  Jack Benjamin Greisman ,  Paul Maragakis ,  Sathesh Bhat ,  Markus Kristofer Dahlgren ,  Eric Therrien

IPC: A61K31/4985 ,  C07D487/04 ,  C07D519/00

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions thereof and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

公开(公告)号：US11629145B2

公开(公告)日：2023-04-18

申请号：US16344061

申请日：2017-10-24

Applicant: Relay Therapeutics, Inc. ,  D. E. Shaw Research, LLC

Inventor： Fabrizio Giordanetto ,  Jack Benjamin Greisman ,  Paul Maragakis ,  Alexander M. Taylor ,  Lucian V. Dipietro ,  Elizabeth H. Kelley ,  André Lescarbeau ,  Mark Andrew Murcko ,  Levi Charles Thomas Pierce ,  Kelley C. Shortsleeves ,  W. Patrick Walters ,  Sathesh Bhat ,  Eric Therrien ,  Markus Kristofer Dahlgren

IPC: C07D487/04 ,  C07D519/00

Abstract: The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the invention. The present invention further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds ad compositions of the invention.