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公开(公告)号：US20130259859A1
公开(公告)日：2013-10-03
申请号：US13852402
申请日：2013-03-28
申请人： Rene Georg OTT , Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Marie-Ange BUYSE , Erik DEPLA , Pascal MERCHIERS , Frederik STEVENAERT
发明人： Rene Georg OTT , Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Marie-Ange BUYSE , Erik DEPLA , Pascal MERCHIERS , Frederik STEVENAERT
IPC分类号： C07K16/22 , A61K45/06 , A61K39/395
摘要： Ang2-binding molecules, preferably Ang2-binding immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with Ang2-mediated effects on angiogenesis. Nucleic acids encoding Ang2-binding molecules, host cells and methods for preparing same.
摘要翻译： Ang2结合分子，优选Ang2结合免疫球蛋白单可变结构域如VHH和结构域抗体，含有它们的药物组合物及其在治疗与Ang2介导的对血管发生的作用相关的疾病中的用途。 编码Ang2-结合分子的核酸，宿主细胞及其制备方法。
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公开(公告)号：US20130078248A1
公开(公告)日：2013-03-28
申请号：US13433359
申请日：2012-03-29
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , C07K16/18 , C07K16/22 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/62 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Bispecific binding molecules binding to both VEGF and Ang2, preferably in the form of immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing the same and their use in the treatment of diseases that are associated with VEGF- and/or Ang2-mediated effects on angiogenesis are disclosed. Further, nucleic acids encoding bispecific binding molecules, host cells and methods for preparing same are also described.
摘要翻译： 结合VEGF和Ang2两者的双特异性结合分子，优选以免疫球蛋白单可变结构域（如VHH和结构域抗体）的形式，含有它们的药物组合物及其在治疗与VEGF-和/或Ang2介导的疾病相关的疾病中的用途 公开了对血管发生的作用。 此外，还描述了编码双特异性结合分子的核酸，宿主细胞及其制备方法。
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公开(公告)号：US20130078247A1
公开(公告)日：2013-03-28
申请号：US13433354
申请日：2012-03-29
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , C07K16/18 , C07K16/22 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/74 , C07K2317/76 , C07K2317/90 , C07K2317/92
摘要： Bispecific binding molecules binding to both DII4 and Ang2, preferably in the form of immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing the same and their use in the treatment of diseases that are associated with DII4- and/or Ang2-mediated effects on angiogenesis are disclosed. Further, nucleic acids encoding bispecific binding molecules, host cells and methods for preparing same are also described.
摘要翻译： 结合DII4和Ang2的双特异性结合分子，优选以免疫球蛋白单可变结构域（如VHH和结构域抗体）的形式，含有它们的药物组合物及其在治疗与DII4和/或Ang2介导的疾病相关的疾病中的用途 公开了对血管发生的作用。 此外，还描述了编码双特异性结合分子的核酸，宿主细胞及其制备方法。
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