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公开(公告)号:US09198875B2
公开(公告)日:2015-12-01
申请号:US12542267
申请日:2009-08-17
CPC分类号: A61K9/7007 , A61L27/34 , A61L27/54 , A61L27/58 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/604 , A61L2300/608 , A61L2300/802 , C08L5/16
摘要: A decomposable thin film includes a plurality of multilayer units including a first layer having a first charge and a second layer having a second charge, wherein at least a portion of the multilayers includes a polymeric cyclodextrin associated with a bioactive agent, wherein decomposition of the thin film is characterized by sequential removal of at least a portion of the layers having the first charge and degradation of layers having the second charge and by release of the bioactive agent from a corresponding layers; wherein the decomposable thin film including at least one degradable polyelectrolyte layer that is hydrolyzable.
摘要翻译: 可分解的薄膜包括多个多层单元,其包括具有第一电荷的第一层和具有第二电荷的第二层,其中至少一部分多层包含与生物活性剂缔合的聚合物环糊精,其中薄层的分解 膜的特征在于顺序去除具有第一电荷的第一电荷和降解的层的至少一部分,并且通过从相应的层释放生物活性剂; 其中所述可分解薄膜包括至少一种可水解的可降解聚电解质层。
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公开(公告)号:US20100040674A1
公开(公告)日:2010-02-18
申请号:US12542267
申请日:2009-08-17
IPC分类号: A61K9/70 , A61K31/4178
CPC分类号: A61K9/7007 , A61L27/34 , A61L27/54 , A61L27/58 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/604 , A61L2300/608 , A61L2300/802 , C08L5/16
摘要: A decomposable thin film includes a plurality of multilayer units including a first layer having a first charge and a second layer having a second charge, wherein at least a portion of the multilayers includes a polymeric cyclodextrin associated with a bioactive agent, wherein decomposition of the thin film is characterized by sequential removal of at least a portion of the layers having the first charge and degradation of layers having the second charge and by release of the bioactive agent from a corresponding layers; wherein the decomposable thin film including at least one degradable polyelectrolyte layer that is hydrolyzable.
摘要翻译: 可分解的薄膜包括多个多层单元,其包括具有第一电荷的第一层和具有第二电荷的第二层,其中至少一部分多层包含与生物活性剂缔合的聚合物环糊精,其中薄层的分解 膜的特征在于顺序去除具有第一电荷的第一电荷和降解的层的至少一部分,并且通过从相应的层释放生物活性剂; 其中所述可分解薄膜包括至少一种可水解的可降解聚电解质层。
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