公开(公告)号：US20200171439A1

公开(公告)日：2020-06-04

申请号：US16697445

申请日：2019-11-27

Applicant: REPLIGEN CORPORATION

Inventor： Mark A. Perreault ,  John F. Connors, JR. ,  Paul C. Lowell

IPC: B01D63/08 ,  B01D65/00 ,  B01D65/02

Abstract: Cassettes for tangential flow filtration (TFF) are disclosed which reduce assembly and disassembly required for aseptic filtration. Packaging systems and methods for the TFF cassettes are also disclosed.

公开(公告)号：US20210039045A1

公开(公告)日：2021-02-11

申请号：US16940764

申请日：2020-07-28

Applicant: REPLIGEN CORPORATION

Inventor： Mark A. Perreault

IPC: B01D61/14 ,  B01D61/18 ,  B01D61/22 ,  B01D63/16

Abstract: The present disclosure relates to tangential flow filters, membranes, and ultrafiltration membranes, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same. In an aspect, an alternating tangential flow system for continuous processing may include a feed line containing a fluid. A retentate line may be in fluid communication with the feed line. A first diaphragm may be at an inlet of the retentate line configured to pump fluid toward an outlet of the retentate line. A second diaphragm may be at the outlet of the retentate line configured to pump fluid toward the inlet of the retentate line. A membrane may be in fluid communication with the retentate line between the first diaphragm and the second diaphragm. A retentate pump may be at the retentate outlet configured to pump the fluid out of the retentate line.

公开(公告)号：US11524262B2

公开(公告)日：2022-12-13

申请号：US16940764

申请日：2020-07-28

Applicant: REPLIGEN CORPORATION

Inventor： Mark A. Perreault

IPC: B01D61/14 ,  B01D61/18 ,  B01D61/22 ,  B01D63/16 ,  B01D65/08

Abstract: The present disclosure relates to tangential flow filters, membranes, and ultrafiltration membranes, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same. In an aspect, an alternating tangential flow system for continuous processing may include a feed line containing a fluid. A retentate line may be in fluid communication with the feed line. A first diaphragm may be at an inlet of the retentate line configured to pump fluid toward an outlet of the retentate line. A second diaphragm may be at the outlet of the retentate line configured to pump fluid toward the inlet of the retentate line. A membrane may be in fluid communication with the retentate line between the first diaphragm and the second diaphragm. A retentate pump may be at the retentate outlet configured to pump the fluid out of the retentate line.

公开(公告)号：US11511232B2

公开(公告)日：2022-11-29

申请号：US17103244

申请日：2020-11-24

Applicant: REPLIGEN CORPORATION

Inventor： Mark A. Perreault

IPC: B01D63/08 ,  B01D65/00

Abstract: Tangential flow filtration systems utilizing flexible bags for permeate collection are provided.

公开(公告)号：US20220026160A1

公开(公告)日：2022-01-27

申请号：US17374050

申请日：2021-07-13

Applicant: Repligen Corporation

Inventor： Mark A. Perreault

IPC: F28D9/00 ,  F28F3/10 ,  F28F9/007

Abstract: A dual path heat exchanger integrated as a single unit able to process fluid stream through a continuous, single-use high temperature short time process. The heat exchanger contains both a heating section and a cooling section in the same unit. In one embodiment, the heating and cooling sections (which may be formed separately for other uses) are formed as a plate and frame structure with a thermally conductive thin film or foil forming the physical barrier between the process stream flow path and the thermal medium (heating or cooling) flow path. The film/foil renders the heat exchanger suitable for single-use and/or to be disposable. A manifold, which also may be formed as a single unit, may be used to transfer fluid flow between the sections of the heat exchanger, and/or to transfer fluid into and out of the system formed by the heat exchanger and manifold.