公开(公告)号：US20020188003A1

公开(公告)日：2002-12-12

申请号：US10155012

申请日：2002-05-28

Applicant: Research Triangle Institute

Inventor： Michael J. Kuhar ,  Frank Ivy Carroll ,  John W. Boja ,  Anita H. Lewin ,  Philip Abraham

IPC: C07D413/02 ,  A61K031/46

CPC classification number: C07D451/02 ,  A61K51/0448 ,  A61K2123/00 ,  C07F7/2208

Abstract: Tropane derivatives having a high binding affinity and selectivity for dopamine transporters bear, on the tropane backbone either a carboxylic ester or isoxazole moiety, as well as a substituted phenyl moiety. The compounds have utility both as pharmaceutical and as imaging agents, when one or more atoms are radioactive.

Abstract translation: 对于多巴胺转运蛋白具有高结合亲和性和选择性的托烷衍生物在托烷骨架上具有羧酸酯或异恶唑部分以及取代的苯基部分。 当一个或多个原子是放射性的时，这些化合物既用作药物也可用作成像剂。