公开(公告)号：US20040266804A1

公开(公告)日：2004-12-30

申请号：US10608207

申请日：2003-06-30

Applicant: Research Triangle Institute

Inventor： Monroe E. Wall ,  Mansukh C. Wani ,  Govindarajan Manikumar ,  Michael A. Wall

IPC: C07D491/14 ,  C07D471/02

CPC classification number: C07D471/14

Abstract: Camptothecin analogs having an E-ring ketone are effective anti tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I DNA cleavable complex.

Abstract translation: 具有E环酮的喜树碱类似物是有效的抗肿瘤化合物。 这些化合物抑制酶拓扑异构酶I，并且可以将相关的拓扑异构酶I DNA可切割复合物的DNA烷基化。