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1.发明申请COMPOSITIONS AND METHODS FOR UPREGULATING HIPPOCAMPAL PLASTICITY AND HIPPOCAMPUS-DEPENDENT LEARNING AND MEMORY 审中-公开用于上调海马塑性和依赖海马学习和记忆的组合物和方法公开(公告)号：US20150050344A1
公开(公告)日：2015-02-19
申请号：US14339387
申请日：2014-07-23
CPC分类号： A61K9/51 , A61K9/08 , A61K33/00 , A61K45/06 , A61K2300/00
摘要： Provided are methods for enhancing hippocampal plasticity and hippocampal-mediated learning and memory, and/or enhancing the synaptic maturation of neurons, and/or optimizing or enhancing neuronal synaptic transmission, and/or enhancing intracellular oxygen delivery or utilization, and/or enhancing ATP synthesis, comprising administration, to a subject in need thereof of a sufficient amount over a sufficient time, of an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures (e.g., nanobubbles) having an average diameter of less than 100 nm (e.g., in at least one subject group selected from but not limited to normal subjects, subjects recovering from neurological trauma (e.g., accidents or injury to the brain, stroke, oxygen deprivation, drowning, and asphyxia), and subjects with learning disorders (e.g., dyslexia, dyscalculia, dysgraphia, dyspraxia (sensory integration disorder), dysphasia/aphasia, auditory processing disorder, non-verbal learning disorder, visual processing disorder, and attention deficit disorder (ADD)).
摘要翻译： 提供了用于增强海马可塑性和海马介导的学习和记忆，和/或增强神经元的突触成熟和/或优化或增强神经元突触传递和/或增强细胞内氧递送或利用和/或增强ATP的方法 合成，包括给予有需要的受试者在足够的时间内足够量的具有平均直径小于100nm的电荷稳定的含氧纳米结构（例如纳米气泡）的离子水溶液（例如， 在选自但不限于正常受试者的至少一个受试者群体中，从神经创伤（例如事故或脑损伤，中风，缺氧，溺水和窒息）恢复的受试者以及学习障碍（例如阅读障碍 ，dyscalculia，dysgraphia，dyspraxia（感觉整合障碍），dysphasia /失语症，听觉加工障碍，非语言学习障碍，视觉 加工障碍和注意缺陷障碍（ADD））。
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公开(公告)号：US20210177891A1
公开(公告)日：2021-06-17
申请号：US17187437
申请日：2021-02-26
摘要： Some embodiments include methods of treating, inhibiting, or ameliorating ischemic stroke or a symptom thereof in a subject. Some embodiments include oxygenated fluid for use in treating, inhibiting, or ameliorating ischemic stroke. The oxygenated fluid may comprise charge-stabilized oxygen-containing nanostructures.
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公开(公告)号：US20200061103A1
公开(公告)日：2020-02-27
申请号：US16597703
申请日：2019-10-09
发明人： Andreas Kalmes , Supurna Ghosh
摘要： Some embodiments herein include methods of ameliorating, inhibiting, reducing, treating, slowing the progression of, or preventing a decline in respiratory function associated with a neurological disease of a patient, for example amyotrophic lateral sclerosis (ALS). Some embodiments herein include methods of ameliorating, inhibiting, reducing the symptoms of, treating, slowing the progression of, or preventing a neurological disease of a patient, in which the neurological disease comprises a decline in respiratory function. Some embodiments include methods of deferring an ALS intervention in an ALS patient.
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4.发明申请COMPOSITIONS AND METHODS FOR ENHANCING NEURONAL PHOSPHORYLATION HOMEOSTASIS, AND MODULATING DYSFUNCTIONAL EXOCYTOSIS AND NEUROTRANSMITTER RELEASE 审中-公开用于增强神经磷酸化的组合物和方法，以及调节功能性外分泌和神经递质释放公开(公告)号：US20150202157A1
公开(公告)日：2015-07-23
申请号：US14603305
申请日：2015-01-22
CPC分类号： A61K33/00
摘要： Provided are methods for treating pre-neuronal loss abnormalities in synaptic function, comprising administrating to a subject having neurons, an ionic aqueous solution comprising charge-stabilized oxygen-containing nanostructures having an average diameter of less than 100 nm in an amount and for a time period sufficient for preventing or reducing abnormalities in synaptic function that precede neuronal loss and/or NFTs formation in taupathies. Also provided are methods for treating pre-neuronal loss abnormalities in synaptic function, comprising contacting neurons in vitro or ex vivo with an ionic aqueous solution comprising charge-stabilized oxygen-containing nanostructures having an average diameter of less than 100 nm in an amount and for a time period sufficient for preventing or reducing abnormalities in synaptic function that precede neuronal loss and/or NFTs formation.
摘要翻译： 提供了用于治疗突触功能中的神经元前损失异常的方法，包括向具有神经元的受试者施用包含平均直径小于100nm的电荷稳定的含氧纳米结构的离子水溶液，其量和一段时间 足以预防或减少先天性神经元损失和/或NFTs形成的突触功能的异常。 还提供了用于治疗突触功能中的神经元前损失异常的方法，其包括将体外或离体的神经元与包含平均直径小于100nm的电荷稳定的含氧纳米结构的离子水溶液接触，所述电荷稳定的含氧纳米结构的量为 足以预防或减少在神经元损失和/或NFT形成之前的突触功能异常的时间段。
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