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公开(公告)号:US20080293691A1
公开(公告)日:2008-11-27
申请号:US12094672
申请日:2006-11-29
IPC分类号: A61K31/506 , A61P9/00 , A61K31/55
CPC分类号: A61K31/506 , A61K31/55 , A61K31/7052 , A61K39/395 , Y02P20/582 , A61K2300/00
摘要: The present invention is directed to methods of treating an ocular neovascular disorder in a mammal by administration of pyrimidine derivatives, benzodiazepinyl derivatives and pharmaceutical compositions containing the same. The invention encompasses methods of treating an ocular neovascular disorder by administration of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, (S)-3-oxo-8-[3-(pyridin-2-ylamino)-1-propyloxy]-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetic acid or salts or solvates thereof. Combination therapies for the treatment of ocular neovascular disorders are also encompassed.
摘要翻译: 本发明涉及通过施用嘧啶衍生物,苯并二氮杂基衍生物和含有它们的药物组合物来治疗哺乳动物眼部新血管障碍的方法。 本发明包括通过施用5 - [[4 - [(2,3-二甲基-2H-吲唑-6-基)甲基氨基] -2-嘧啶基]氨基] -2-甲基苯磺酰胺处理眼新生血管障碍的方法, S)-3-氧代-8- [3-(吡啶-2-基氨基)-1-丙氧基] -2-(2,2,2-三氟乙基)-2,3,4,5-四氢-1H- - 苯并氮杂-4-乙酸或其盐或溶剂化物。 还包括用于治疗眼新生血管障碍的联合疗法。