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1.发明授权公开(公告)号：US08952214B2
公开(公告)日：2015-02-10
申请号：US12823243
申请日：2010-06-25
IPC分类号： A01K67/027
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , C07H21/04 , C07K14/705
摘要： A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel β subunit, wherein said promoter construct directs expression of the epithelial sodium channel β subunit in lung epithelial cells of said animal, and wherein said transgenic mammal has increased lung mucus retention as compared to the corresponding wild-type mammal. The animal is useful in screening compounds for activity in treating lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease.
摘要翻译： 描述了一种非人类转基因哺乳动物，其基因组包含与编码上皮钠通道的异源DNA可操作地连接的启动子构建体; 亚基，其中所述启动子构建体指导上皮钠通道的表达; 所述动物的肺上皮细胞中的亚单位，并且其中所述转基因哺乳动物与相应的野生型哺乳动物相比具有增加的肺粘液滞留。 该动物用于筛选用于治疗肺部疾病如囊性纤维化和慢性阻塞性肺疾病的活性的化合物。
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2.发明申请ANIMAL MODEL FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND CYSTIC FIBROSIS 有权慢性阻塞性肺疾病和CYSTIC FIBROSIS的动物模型公开(公告)号：US20100263064A1
公开(公告)日：2010-10-14
申请号：US12823243
申请日：2010-06-25
IPC分类号： A01K67/027 , A61K49/00
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , C07H21/04 , C07K14/705
摘要： A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel β subunit, wherein said promoter construct directs expression of the epithelial sodium channel β subunit in lung epithelial cells of said animal, and wherein said transgenic mammal has increased lung mucus retention as compared to the corresponding wild-type mammal. The animal is useful in screening compounds for activity in treating lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease.
摘要翻译： 描述了一种非人类转基因哺乳动物，其基因组包含与编码上皮钠通道的异源DNA可操作地连接的启动子构建体; 亚基，其中所述启动子构建体指导上皮钠通道的表达; 所述动物的肺上皮细胞中的亚单位，并且其中所述转基因哺乳动物与相应的野生型哺乳动物相比具有增加的肺粘液滞留。 该动物用于筛选用于治疗肺部疾病如囊性纤维化和慢性阻塞性肺疾病的活性的化合物。
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3.发明申请ANIMAL MODEL FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND CYSTIC FIBROSIS 有权慢性阻塞性肺疾病和CYSTIC FIBROSIS的动物模型公开(公告)号：US20090019555A1
公开(公告)日：2009-01-15
申请号：US12233869
申请日：2008-09-19
IPC分类号： A61K51/00 , C07H21/04 , A01K67/027
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , C07H21/04 , C07K14/705
摘要： A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel β subunit, wherein said promoter construct directs expression of the epithelial sodium channel β subunit in lung epithelial cells of said animal, and wherein said transgenic mammal has increased lung mucus retention as compared to the corresponding wild-type mammal. The animal is useful in screening compounds for activity in treating lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease.
摘要翻译： 描述了一种非人类转基因哺乳动物，其基因组包含与编码上皮钠通道β亚基的异源DNA可操作地连接的启动子构建体，其中所述启动子构建体指导所述动物的肺上皮细胞中上皮钠通道β亚基的表达，其中所述 与相应的野生型哺乳动物相比，转基因哺乳动物具有增加的肺粘液滞留。 该动物用于筛选用于治疗肺部疾病如囊性纤维化和慢性阻塞性肺疾病的活性的化合物。
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4.发明授权公开(公告)号：US07772458B2
公开(公告)日：2010-08-10
申请号：US12233869
申请日：2008-09-19
IPC分类号： G01N33/00 , A01K67/00 , A01K67/033 , A01K67/027
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , C07H21/04 , C07K14/705
摘要： A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel β subunit, wherein said promoter construct directs expression of the epithelial sodium channel β subunit in lung epithelial cells of said animal, and wherein said transgenic mammal has increased lung mucus retention as compared to the corresponding wild-type mammal. The animal is useful in screening compounds for activity in treating lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease.
摘要翻译： 描述了一种非人类转基因哺乳动物，其基因组包含与编码上皮钠通道的异源DNA可操作地连接的启动子构建体; 亚基，其中所述启动子构建体指导上皮钠通道的表达; 所述动物的肺上皮细胞中的亚单位，并且其中所述转基因哺乳动物与相应的野生型哺乳动物相比具有增加的肺粘液滞留。 该动物用于筛选用于治疗肺部疾病如囊性纤维化和慢性阻塞性肺疾病的活性的化合物。
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5.发明授权公开(公告)号：US07514593B2
公开(公告)日：2009-04-07
申请号：US10448784
申请日：2003-05-30
IPC分类号： A01K67/027 , C07H21/02 , C07H21/04
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , C07H21/04 , C07K14/705
摘要： A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel β subunit, wherein said promoter construct directs expression of the epithelial sodium channel β subunit in lung epithelial cells of said animal, and wherein said transgenic mammal has increased lung mucus retention as compared to the corresponding wild-type mammal. The animal is useful in screening compounds for activity in treating lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease.
摘要翻译： 描述了一种非人类转基因哺乳动物，其基因组包含与编码上皮钠通道β亚基的异源DNA可操作地连接的启动子构建体，其中所述启动子构建体指导所述动物的肺上皮细胞中上皮钠通道β亚基的表达，其中所述 与相应的野生型哺乳动物相比，转基因哺乳动物具有增加的肺粘液滞留。 该动物用于筛选用于治疗肺部疾病如囊性纤维化和慢性阻塞性肺疾病的活性的化合物。
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6.发明申请公开(公告)号：US20090312348A1
公开(公告)日：2009-12-17
申请号：US12522369
申请日：2008-01-07
申请人： Marcus Mall
发明人： Marcus Mall
IPC分类号： A61K31/4965
CPC分类号： A61K31/4965
摘要： The present invention relates to a blocker of sodium channels in cell membranes, particularly in membranes of epithelial cells of organs belonging to the respiratory tract to be used as the pharmaceutically active ingredient in a medicament for treating an obstructive lung disease in a patient.
摘要翻译： 本发明涉及在用于治疗患者中的阻塞性肺病的药物中用作药物活性成分的细胞膜中的钠通道阻断剂，特别是在属于呼吸道的器官的上皮细胞的膜中。
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