公开(公告)号：US6022880A

公开(公告)日：2000-02-08

申请号：US901557

申请日：1997-07-28

申请人： Richard Charles Effland ,  Joseph Thomas Klein ,  Lawrence Leo Martin ,  Gregory M. Shutske ,  Kevin J. Kapples ,  John D. Tomer, IV

发明人： Richard Charles Effland ,  Joseph Thomas Klein ,  Lawrence Leo Martin ,  Gregory M. Shutske ,  Kevin J. Kapples ,  John D. Tomer, IV

IPC分类号： A61K31/44 ,  A61K31/42 ,  A61K31/425 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/47 ,  A61P1/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  C07D401/12 ,  C07D401/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

CPC分类号： C07D401/12 ,  C07D409/12 ,  C07D413/10 ,  C07D417/12

摘要： There are disclosed various compounds of the formula below, ##STR1## where R, R.sub.1, W, X, Y and Z are as defined in the specification; which are useful for alleviating various memory dysfunctions such as Alzheimer's disease, as modulators of neurotransmitter functions such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antienmtics, and for the treatment of personality disorders such as obsessive compulsive disorder.

摘要翻译： 公开了下式的各种化合物，其中R，R 1，W，X，Y和Z如说明书中所定义; 其可用于缓解诸如阿尔茨海默病的各种记忆功能障碍，作为神经递质功能如5-羟色胺能和肾上腺素能的调节剂，并且因此可用作抗抑郁药，抗焦虑药，非典型抗精神病药，抗宁药物和治疗人格障碍如强迫症 紊乱。

公开(公告)号：US5856335A

公开(公告)日：1999-01-05

申请号：US780525

申请日：1997-01-08

申请人： Richard Charles Effland ,  Joseph Thomas Klein ,  Lawrence Leo Martin

发明人： Richard Charles Effland ,  Joseph Thomas Klein ,  Lawrence Leo Martin

IPC分类号： A61K31/40 ,  A61K31/435 ,  A61P1/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  A61P43/00 ,  C07D495/04 ,  C07D471/04 ,  A61K31/44 ,  C07D487/04

CPC分类号： C07D495/04

摘要： This application relates to compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, m and n are as defined in the specification which are useful as modulators of neurotransmitter function such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorders. Certain of the compounds are also useful as glycine partial agonists.

摘要翻译： 本申请涉及式IMA的化合物，其中R 1，R 2，R 3，m和n如说明书中所定义，其可用作神经递质功能的调节剂如5-羟色胺能和肾上腺素能，因此可用作抗抑郁药，抗焦虑药 ，非典型抗精神病药，止吐药，以及治疗人格障碍如强迫症。 某些化合物也可用作甘氨酸部分激动剂。