公开(公告)号：US07947742B2

公开(公告)日：2011-05-24

申请号：US10607571

申请日：2003-06-26

申请人： Richard P. Batycky ,  Giovanni Caponetti ,  Mariko Childs ,  Elliot Ehrich ,  Karen Fu ,  Jeffrey S. Hrkach ,  Wen-I Li ,  Michael M. Lipp ,  Mei-Ling Pan ,  Jason Summa

发明人： Richard P. Batycky ,  Giovanni Caponetti ,  Mariko Childs ,  Elliot Ehrich ,  Karen Fu ,  Jeffrey S. Hrkach ,  Wen-I Li ,  Michael M. Lipp ,  Mei-Ling Pan ,  Jason Summa

IPC分类号： A61K31/137 ,  A61K9/14 ,  A61K9/00

CPC分类号： A61K31/137 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/1617 ,  A61K31/135 ,  A61M15/0091 ,  A61M2202/06

摘要： The present invention is directed toward particles for delivery of epinephrine to the respiratory system and methods for treating a patient in need of epinephrine. The particles and respirable compositions comprising the particles of the present invention described herein comprise the bioactive agent epinephrine, or a salt thereof, as a therapeutic agent. The particles are preferably formed by spray drying. Preferably, the particles and the respirable compositions are substantially dry and are substantially free of propellents. In a preferred embodiment, the particles have aerodynamic characteristics that permit targeted delivery of epinephrine to the site(s) of action.

摘要翻译： 本发明涉及将肾上腺素递送至呼吸系统的颗粒和用于治疗需要肾上腺素的患者的方法。 包含本文所述的本发明的颗粒的颗粒和可呼吸组合物包含作为治疗剂的生物活性剂肾上腺素或其盐。 颗粒优选通过喷雾干燥形成。 优选地，颗粒和可呼吸组合物基本上是干燥的并且基本上不含推进剂。 在优选的实施方案中，颗粒具有允许将肾上腺素靶向递送至作用部位的空气动力特性。

公开(公告)号：US08415397B2

公开(公告)日：2013-04-09

申请号：US13082626

申请日：2011-04-08

申请人： Richard P. Batycky ,  Giovanni Caponetti ,  Mariko Childs ,  Elliot Ehrich ,  Karen Fu ,  Jeffrey S. Hrkach ,  Wen-I Li ,  Michael M. Lipp ,  Mei-Ling Pan ,  Jason Summa

发明人： Richard P. Batycky ,  Giovanni Caponetti ,  Mariko Childs ,  Elliot Ehrich ,  Karen Fu ,  Jeffrey S. Hrkach ,  Wen-I Li ,  Michael M. Lipp ,  Mei-Ling Pan ,  Jason Summa

IPC分类号： A61K9/14 ,  A61K31/13 ,  A61K31/135 ,  A61K31/045

CPC分类号： A61K31/137 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/1617 ,  A61K31/135 ,  A61M15/0091 ,  A61M2202/06

摘要： The present invention is directed toward particles for delivery of epinephrine to the respiratory system and methods for treating a patient in need of epinephrine. The particles and respirable compositions comprising the particles of the present invention described herein comprise the bioactive agent epinephrine, or a salt thereof, as a therapeutic agent. The particles are preferably formed by spray drying. Preferably, the particles and the respirable compositions are substantially dry and are substantially free of propellents. In a preferred embodiment, the particles have aerodynamic characteristics that permit targeted delivery of epinephrine to the site(s) of action.

摘要翻译： 本发明涉及将肾上腺素递送至呼吸系统的颗粒和用于治疗需要肾上腺素的患者的方法。 包含本文所述的本发明的颗粒的颗粒和可呼吸组合物包含作为治疗剂的生物活性剂肾上腺素或其盐。 颗粒优选通过喷雾干燥形成。 优选地，颗粒和可呼吸组合物基本上是干燥的并且基本上不含推进剂。 在优选的实施方案中，颗粒具有允许将肾上腺素靶向递送至作用部位的空气动力特性。

公开(公告)号：US20110237681A1

公开(公告)日：2011-09-29

申请号：US13082626

申请日：2011-04-08

申请人： Richard P. Batycky ,  Giovanni Caponetti ,  Mariko Childs ,  Elliot Ehrich ,  Karen Fu ,  Jeffrey S. Hrkach ,  Wen-I Li ,  Michael M. Liip ,  Mei-Ling Pan ,  Jason Summa

发明人： Richard P. Batycky ,  Giovanni Caponetti ,  Mariko Childs ,  Elliot Ehrich ,  Karen Fu ,  Jeffrey S. Hrkach ,  Wen-I Li ,  Michael M. Liip ,  Mei-Ling Pan ,  Jason Summa

IPC分类号： A61K31/138 ,  A61P25/00 ,  A61P37/08

CPC分类号： A61K31/137 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/1617 ,  A61K31/135 ,  A61M15/0091 ,  A61M2202/06

摘要： The present invention is directed toward particles for delivery of epinephrine to the respiratory system and methods for treating a patient in need of epinephrine. The particles and respirable compositions comprising the particles of the present invention described herein comprise the bioactive agent epinephrine, or a salt thereof, as a therapeutic agent. The particles are preferably formed by spray drying. Preferably, the particles and the respirable compositions are substantially dry and are substantially free of propellents. In a preferred embodiment, the particles have aerodynamic characteristics that permit targeted delivery of epinephrine to the site(s) of action.

摘要翻译： 本发明涉及将肾上腺素递送至呼吸系统的颗粒和用于治疗需要肾上腺素的患者的方法。 包含本文所述的本发明的颗粒的颗粒和可呼吸组合物包含作为治疗剂的生物活性剂肾上腺素或其盐。 颗粒优选通过喷雾干燥形成。 优选地，颗粒和可呼吸组合物基本上是干燥的并且基本上不含推进剂。 在优选的实施方案中，颗粒具有允许将肾上腺素靶向递送至作用部位的空气动力特性。