Correlation of anti-cancer activity of dyes with redox potentials
    3.
    发明申请
    Correlation of anti-cancer activity of dyes with redox potentials 审中-公开
    染料与氧化还原电位的抗癌活性的相关性

    公开(公告)号:US20060099712A1

    公开(公告)日:2006-05-11

    申请号:US10983369

    申请日:2004-11-08

    IPC分类号: G01N33/00

    摘要: The present invention relates to a method for selecting pharmacological compounds for selective inhibition of cancer cells comprising identifying a compound, determining the reduction potential (ER) of the compound, and selecting the compound which has a reduction potential from −1.1 to −0.8 volts. The invention also relates to a pharmacological compound comprising at least one cyanine dye or merocyanine dye, wherein the dye has at least one cationic substituent, wherein the dye has a reduction potential of from—1.1 to 0.8 volts, and wherein the pharmacological compound demonstrates selective inhibition of cancer cells.

    摘要翻译: 本发明涉及选择性抑制癌细胞的药理化合物的选择方法,包括鉴定化合物,测定化合物的还原电位(E SUB R R),并选择具有还原电位的化合物 从-1.1到-0.8伏。 本发明还涉及包含至少一种花青染料或部花青染料的药理化合物,其中所述染料具有至少一个阳离子取代基,其中所述染料具有从1.1至0.8伏特的还原电位,并且其中所述药物化合物显示出选择性 抑制癌细胞。