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1.
公开(公告)号:US20120004137A1
公开(公告)日:2012-01-05
申请号:US13147898
申请日:2010-02-16
申请人: Richard W. Wagner , Yan Chen , Steven Mark Shamah
发明人: Richard W. Wagner , Yan Chen , Steven Mark Shamah
CPC分类号: C12Q1/6897 , C12N15/1068 , C12N15/1075 , C12Q2563/107 , C12Q2525/207 , C12Q2525/205 , C12Q2565/626 , C12Q2525/203 , C12Q2525/197
摘要: The present invention features methods and compositions for the identification of molecules that facilitate the intracellular delivery of a, e.g., nucleic acid molecule. The methods and compositions of the invention utilize any display methodology wherein a library (e.g., a small molecule or protein library) is coupled to a nucleic acid (e.g., RNA or DNA) that encodes each library member.
摘要翻译: 本发明的特征在于用于鉴定促进例如核酸分子的细胞内递送的分子的方法和组合物。 本发明的方法和组合物利用任何显示方法,其中文库(例如,小分子或蛋白质文库)与编码每个文库成员的核酸(例如RNA或DNA)偶联。