公开(公告)号：US06465715B1

公开(公告)日：2002-10-15

申请号：US09526993

申请日：2000-03-16

申请人： Richard Zwaal ,  Wouter Asaert ,  Ingele Roelens ,  Thierry Bogaert

发明人： Richard Zwaal ,  Wouter Asaert ,  Ingele Roelens ,  Thierry Bogaert

IPC分类号： G01N3300

CPC分类号： C12N15/85 ,  A01K67/0336 ,  A01K2217/05 ,  C07K14/43545 ,  C12N2830/00 ,  C12N2830/75

摘要： DNA fragments from the promoter region of the C. elegans UL6 gene which are capable of functioning as promoters directing gene expression in the excretory cell of C. elegans are provided and also expression vectors and transgenic C. elegans containing these fragments. Also provided are screening methods performed in C. elegans for identifying compounds or mutations which have an affect on the morphology of the excretory canal. Compounds identified using these screening methods may have therapeutic potential in the treatment of a range of diseases for which the C. elegans excretory canal serves as a model.

摘要翻译： 提供能够作为引导秀丽隐杆线虫排泄细胞中的基因表达的启动子的秀丽隐杆线虫UL6基因的启动子区域的DNA片段，以及含有这些片段的表达载体和转基因秀丽隐杆线虫。 还提供了在线虫中进行的用于鉴定对排泄管形态有影响的化合物或突变的筛选方法。 使用这些筛选方法鉴定的化合物可能具有处理线虫排泄管作为模型的一系列疾病的治疗潜力。