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公开(公告)号：US06680311B1
公开(公告)日：2004-01-20
申请号：US09029190
申请日：1998-02-25
申请人： Rima S Al-Awar , William J Ehlhardt , Subbaraju V Gottumukkala , Michael J Martinelli , Eric D Moher , Richard E Moore , John E Munroe , Bryan H Norman , Vinod F Patel , James E Ray , Chuan Shih , John E Toth , Venkatraghavan Vasudevan
发明人： Rima S Al-Awar , William J Ehlhardt , Subbaraju V Gottumukkala , Michael J Martinelli , Eric D Moher , Richard E Moore , John E Munroe , Bryan H Norman , Vinod F Patel , James E Ray , Chuan Shih , John E Toth , Venkatraghavan Vasudevan
IPC分类号： A61K3133
CPC分类号： C07D273/00 , C07D413/06 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/14 , C07F9/12 , C07F9/6527
摘要： The present invention provides cryptophycin compounds of Formula I that are useful in the treatment of neoplasms.
摘要翻译： 本发明提供式I的cryptophycin化合物，其可用于治疗赘生物。
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公开(公告)号：US06221876B1
公开(公告)日：2001-04-24
申请号：US09646063
申请日：2000-09-13
IPC分类号： A61K3147
CPC分类号： C07D498/04
摘要： The present invention relates to a compound of formula (I) which is useful for inhibiting neoplasms where the resistance is conferred in part or in total by MRP1.
摘要翻译： 本发明涉及可用于抑制由MRP1部分或全部赋予抗性的肿瘤的式（I）化合物。
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公开(公告)号：US06512121B2
公开(公告)日：2003-01-28
申请号：US09878452
申请日：2001-06-11
申请人： John J Talley , James A Sikorski , Matthew J Graneto , Jeffrey S Carter , Bryan H Norman , Balekudru Devadas , Hwang-Fun Lu
发明人： John J Talley , James A Sikorski , Matthew J Graneto , Jeffrey S Carter , Bryan H Norman , Balekudru Devadas , Hwang-Fun Lu
IPC分类号： C07D26332
CPC分类号： C07D231/12 , C07D263/32
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
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公开(公告)号：US06417193B1
公开(公告)日：2002-07-09
申请号：US09646074
申请日：2000-09-13
申请人： Joseph M Gruber , Bryan H Norman
发明人： Joseph M Gruber , Bryan H Norman
IPC分类号： A61K31443
CPC分类号： C07D498/04 , A61K31/4745
摘要： The present invention relates to a compound of formula (I) which is useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
摘要翻译： 本发明涉及式（I）化合物，其可用于抑制MRP1部分或全部赋予抗性的抗性赘生物。
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5.发明授权公开(公告)号：US06432999B1
公开(公告)日：2002-08-13
申请号：US09878538
申请日：2001-06-11
申请人： John J Talley , James A Sikorski , Matthew J Graneto , Jeffrey S Carter , Bryan H Norman , Balekudru Devadas , Hwang-Fun Lu
发明人： John J Talley , James A Sikorski , Matthew J Graneto , Jeffrey S Carter , Bryan H Norman , Balekudru Devadas , Hwang-Fun Lu
IPC分类号： A61K31415
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
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公开(公告)号：US06369070B1
公开(公告)日：2002-04-09
申请号：US09646062
申请日：2000-09-13
申请人： Joseph M. Gruber , Julian S Kroin , Bryan H Norman
发明人： Joseph M. Gruber , Julian S Kroin , Bryan H Norman
IPC分类号： A61K314355
CPC分类号： A61K31/704 , A61K31/475 , A61K45/06 , C07D498/02 , A61K2300/00
摘要： The present invention relates to a compound of formula (I), which is useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
摘要翻译： 本发明涉及式（I）化合物，其可用于抑制MRP1部分或全部赋予抗性的抗性赘生物。
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7.发明授权公开(公告)号：US06515014B2
公开(公告)日：2003-02-04
申请号：US09878496
申请日：2001-06-11
申请人： John J Talley , James A Sikorski , Matthew J Graneto , Jeffrey S Carter , Bryan H Norman , Balekudru Devadas , Lu Hwang-Fun
发明人： John J Talley , James A Sikorski , Matthew J Graneto , Jeffrey S Carter , Bryan H Norman , Balekudru Devadas , Lu Hwang-Fun
IPC分类号： C07D33324
CPC分类号： C07D231/12 , C07D263/32
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
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