公开(公告)号：US20140141018A1

公开(公告)日：2014-05-22

申请号：US14109267

申请日：2013-12-17

Applicant: Rinat Neuroscience Corp.

Inventor： Chia-Yang LIN ,  Li-Fen LEE ,  Wenwu ZHAI

IPC: C07K16/28

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.

Abstract translation: 本发明提供了结合白细胞介素-7受体（IL-7R）的拮抗性抗体。 本发明还提供了获得这样的抗体和抗体编码核酸的方法。 本发明还涉及这些抗体及其抗原结合部分用于治疗和/或预防2型糖尿病和免疫学障碍（包括1型糖尿病，多发性硬化症，类风湿性关节炎，移植物抗宿主病）的治疗方法 ，和狼疮。