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公开(公告)号：US20100204172A1
公开(公告)日：2010-08-12
申请号：US12597773
申请日：2008-03-12
IPC分类号： A61K31/708 , C07H19/16 , C12N9/99 , C07D475/00 , A61K31/522 , A61P35/00
CPC分类号： C07H19/16 , C07H19/173
摘要： Disclosed are compounds that are AGT inactivators that include a folate residue, e.g., a compound of formula (I), wherein X1, X2, R1, and R2 are as described herein. Also disclosed is a pharmaceutical composition comprising a compound of the invention and a pharmaceutically acceptable carrier. Also disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells and inactivating AGT in a tumor cell. The methods comprise, inter alia, administering a compound or pharmaceutically acceptable salt of formula (I).
摘要翻译： 公开的是包含叶酸残基的AGT灭活剂的化合物，例如式（I）化合物，其中X 1，X 2，R 1和R 2如本文所述。 还公开了包含本发明化合物和药学上可接受的载体的药物组合物。 还公开了增强肿瘤细胞的化学治疗和灭活肿瘤细胞中AGT的方法。 所述方法特别包括施用式（I）的化合物或药学上可接受的盐。
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公开(公告)号：US08188055B2
公开(公告)日：2012-05-29
申请号：US12597773
申请日：2008-03-12
申请人： Robert C. Moschel , Matthew Karl Moschel, legal representative , Anthony E. Pegg , Sahar Javanmard , Natalia Loktionova , Gary Pauly
CPC分类号： C07H19/16 , C07H19/173
摘要： Disclosed are compounds that are AGT inactivators that include a folate residue, e.g., a compound of formula (I), wherein X1, X2, R1, and R2 are as described herein. Also disclosed is a pharmaceutical composition comprising a compound of the invention and a pharmaceutically acceptable carrier. Also disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells and inactivating AGT in a tumor cell. The methods comprise, inter alia, administering a compound or pharmaceutically acceptable salt of formula (I).
摘要翻译： 公开的是包含叶酸残基的AGT灭活剂的化合物，例如式（I）化合物，其中X 1，X 2，R 1和R 2如本文所述。 还公开了包含本发明化合物和药学上可接受的载体的药物组合物。 还公开了增强肿瘤细胞的化学治疗和灭活肿瘤细胞中AGT的方法。 所述方法特别包括施用式（I）的化合物或药学上可接受的盐。
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