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公开(公告)号:US20090012010A1
公开(公告)日:2009-01-08
申请号:US12152488
申请日:2008-05-14
申请人: Robert Galemmo, JR. , Richard Holland , Yanbing Ding , Lingyun Zhang , Gabriel Hum , Navjot Chahal , Joseph Duffy , Christian Stevenson , Andrew Ullman
发明人: Robert Galemmo, JR. , Richard Holland , Yanbing Ding , Lingyun Zhang , Gabriel Hum , Navjot Chahal , Joseph Duffy , Christian Stevenson , Andrew Ullman
IPC分类号: A61K38/05 , C07C233/87 , C07D265/30 , A61P25/16 , A61P25/18 , A61P35/00 , A61P3/10
CPC分类号: A61K31/166 , A61K31/277 , A61K31/4453 , A61K31/5375
摘要: Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type and/or T-type calcium channel activity are disclosed. Specifically, a series of compounds containing both an amino acid functionality and multiple aromatic rings are disclosed of the general formula (1) where X is benzhydryl, or an aromatic or heteroaromatic ring.
摘要翻译: 公开了有效改善特征在于不需要的钙通道活性,特别是不需要的N型和/或T型钙通道活性的病症的方法和化合物。 具体地,公开了一系列含有氨基酸官能团和多个芳环的化合物,其通式(1)其中X是二苯甲基或芳族或杂芳族环。