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公开(公告)号：US07696177B2
公开(公告)日：2010-04-13
申请号：US11922055
申请日：2006-06-09
CPC分类号： C07D405/10 , C07D205/08 , C07H7/033 , C07H7/04 , C07H7/06 , C07H15/18 , C07H15/203
摘要： This invention provides cholesterol absorption inhibitors of Formula (I), and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
摘要翻译： 本发明提供式（I）的胆固醇吸收抑制剂及其药学上可接受的盐和酯。 该化合物可用于降低血浆胆固醇水平，特别是低密度脂蛋白胆固醇，以及用于治疗和预防动脉粥样硬化和动脉粥样硬化疾病事件。
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公开(公告)号：US20100004184A1
公开(公告)日：2010-01-07
申请号：US11922055
申请日：2006-06-09
IPC分类号： A61K31/7052 , C07H7/06 , A61P9/10 , A61P3/00
CPC分类号： C07D405/10 , C07D205/08 , C07H7/033 , C07H7/04 , C07H7/06 , C07H15/18 , C07H15/203
摘要： This invention provides cholesterol absorption inhibitors of Formula (I), and the pharmaceutically acceptable salts and esters thereof. The compounds arc useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
摘要翻译： 本发明提供式（I）的胆固醇吸收抑制剂及其药学上可接受的盐和酯。 该化合物可用于降低血浆胆固醇水平，特别是低密度脂蛋白胆固醇，以及治疗和预防动脉粥样硬化和动脉粥样硬化疾病事件。
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公开(公告)号：US08729104B2
公开(公告)日：2014-05-20
申请号：US13021992
申请日：2011-02-07
申请人： Lin Chu , Ihor E. Kopka , Bing Li , Anthony K. Ogawa , Feroze Ujjainwalla
发明人： Lin Chu , Ihor E. Kopka , Bing Li , Anthony K. Ogawa , Feroze Ujjainwalla
IPC分类号： A61K31/4439 , C07D413/12
CPC分类号： C07D213/30 , C07D401/12 , C07D401/14 , C07D413/12
摘要： The instant invention provides compounds of formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译： 本发明提供了作为5-脂氧合酶活化蛋白抑制剂的式I化合物。 式I的化合物可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护剂。
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公开(公告)号：US20110190346A1
公开(公告)日：2011-08-04
申请号：US13021992
申请日：2011-02-07
申请人： Lin Chu , Ihor E. Kopka , Bing Li , Anthony K. Ogawa , Feroze Ujjainwalla
发明人： Lin Chu , Ihor E. Kopka , Bing Li , Anthony K. Ogawa , Feroze Ujjainwalla
IPC分类号： A61K31/4545 , C07D413/12 , C07D401/12 , C07D211/82 , C07D213/02 , A61K31/44 , A61K31/4439 , A61P9/10
CPC分类号： C07D213/30 , C07D401/12 , C07D401/14 , C07D413/12
摘要： The instant invention provides compounds of formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译： 本发明提供了作为5-脂氧合酶活化蛋白抑制剂的式I化合物。 式I的化合物可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护剂。
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公开(公告)号：US20090258851A1
公开(公告)日：2009-10-15
申请号：US12296117
申请日：2007-04-06
申请人： LIN Chu , Bing Li , Anthony K. Ogawa , Hyun O. Ok , Debra L Ondeyka , Minal Patel , Rosemary Sisco , Feroze Ujjainwalla , Jinyou Xu
发明人： LIN Chu , Bing Li , Anthony K. Ogawa , Hyun O. Ok , Debra L Ondeyka , Minal Patel , Rosemary Sisco , Feroze Ujjainwalla , Jinyou Xu
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/501 , A61K31/506 , A61K31/4545 , A61K31/444 , C07D413/14 , C07D403/14 , C07D401/14 , C07D417/14 , A61P9/10 , A61P11/06
CPC分类号： C07D213/65 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The instant invention provides compounds of Formula II which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula II are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译： 本发明提供了作为5-脂氧合酶活化蛋白抑制剂的式II化合物。 式II的化合物可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护剂。
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公开(公告)号：US08426413B2
公开(公告)日：2013-04-23
申请号：US13403643
申请日：2012-02-23
申请人： Lin Chu , Bing Li , Anthony K. Ogawa , Hyun O. Ok , Debra L. Ondeyka , Minal Patel , Rosemary Sisco , Feroze Ujjainwalla , Jinyou Xu
发明人： Lin Chu , Bing Li , Anthony K. Ogawa , Hyun O. Ok , Debra L. Ondeyka , Minal Patel , Rosemary Sisco , Feroze Ujjainwalla , Jinyou Xu
IPC分类号： A61K31/506 , A61K31/501 , A61K31/444 , C07D401/14 , C07D401/04
CPC分类号： C07D213/65 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The instant invention provides compounds of Formula II which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula II are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译： 本发明提供了作为5-脂氧合酶活化蛋白抑制剂的式II化合物。 式II的化合物可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护剂。
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公开(公告)号：US20120149674A1
公开(公告)日：2012-06-14
申请号：US13403643
申请日：2012-02-23
申请人： Lin Chu , Bing Li , Anthony K. Ogawa , Hyun O. Ok , Debra L. Ondeyka , Minal Patel , Rosemary Sisco , Feroze Ujjainwalla , Jinyou Xu
发明人： Lin Chu , Bing Li , Anthony K. Ogawa , Hyun O. Ok , Debra L. Ondeyka , Minal Patel , Rosemary Sisco , Feroze Ujjainwalla , Jinyou Xu
IPC分类号： A61K31/444 , C07D417/14 , C07D401/14 , A61K31/5377 , A61P11/06 , A61K31/506 , A61K31/4439 , A61K31/501 , A61P9/10 , A61P11/00 , C07D413/14 , A61K31/4545
CPC分类号： C07D213/65 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The instant invention provides compounds of Formula II which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula II are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译： 本发明提供了作为5-脂氧合酶活化蛋白抑制剂的式II化合物。 式II的化合物可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护剂。
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公开(公告)号：US08124628B2
公开(公告)日：2012-02-28
申请号：US12296117
申请日：2007-04-06
申请人： Lin Chu , Bing Li , Anthony K. Ogawa , Hyun O. Ok , Debra L. Ondeyka , Minal Patel , Rosemary Sisco , Feroze Ujjainwalla , Jinyou Xu
发明人： Lin Chu , Bing Li , Anthony K. Ogawa , Hyun O. Ok , Debra L. Ondeyka , Minal Patel , Rosemary Sisco , Feroze Ujjainwalla , Jinyou Xu
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/501 , A61K31/4545 , A61K31/444 , A61K31/4439 , C07D417/14 , C07D413/14 , C07D407/14 , C07D401/14
CPC分类号： C07D213/65 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The instant invention provides compounds of Formula II which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula II are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译： 本发明提供了作为5-脂氧合酶活化蛋白抑制剂的式II化合物。 式II的化合物可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护剂。
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公开(公告)号：US20160347757A1
公开(公告)日：2016-12-01
申请号：US15116659
申请日：2015-02-06
申请人： Santhosh F. NEELAMKAVIL , Scott D. EDMONDSON , Zhuyan GUO , Alan W. HRUZA , Zahid HUSSAIN , Charles A. LESBURG , Remond MONINGKA , Anthony K. OGAWA , Rudrajit MAL , MERCK SHARP & DOHME CORP
发明人： Santhosh F. Neelamkavil , Scott D. Edmondson , Zhuyan Guo , Alan W. Hruza , Zahid Hussain , Charles A. Lesburg , Remond Moningka , Anthony K. Ogawa , Rudrajit Mal
IPC分类号： C07D487/08 , C07D471/08
CPC分类号： C07D487/08 , C07D471/08
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
摘要翻译： 本发明提供式（I）的化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维变化的方法。 该化合物是选择性因子XIa抑制剂或因子XIa和血浆激肽释放酶的双重抑制剂。
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公开(公告)号：US20240190892A1
公开(公告)日：2024-06-13
申请号：US18550332
申请日：2022-03-16
申请人： Natalija Cernaka , Anthony K. OGAWA , Alan C. CHENG , Jianming BAO , Phillip Patrick SHARP , Jovan Alexander LOPEZ , Dong XIAO , Haiqun TANG , Merck Sharp & Dohme LLC
发明人： Natalija Cernaka , Anthony K. Ogawa , Alan C. Cheng , Jianming Bao , Phillip Patrick Sharp , Jovan Alexander Lopez , Dong Xiao , Haiqun Tang
IPC分类号： C07D498/20 , A61K31/5386 , A61K45/06 , C07D519/00
CPC分类号： C07D498/20 , A61K31/5386 , A61K45/06 , C07D519/00
摘要： The present invention provides a compound of formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age-related macular degeneration, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.
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