公开(公告)号：US20080118912A1

公开(公告)日：2008-05-22

申请号：US10598722

申请日：2005-03-10

申请人： Robert Martin Dickson ,  Jie Zheng ,  Lynn Anne Capadona ,  Jeffrey Thomas Petty ,  Sandeep Ajit Patel ,  Marcus Weck

发明人： Robert Martin Dickson ,  Jie Zheng ,  Lynn Anne Capadona ,  Jeffrey Thomas Petty ,  Sandeep Ajit Patel ,  Marcus Weck

IPC分类号： G01N33/543 ,  G01N33/53 ,  C12Q1/68

CPC分类号： G01N33/588 ,  A61K49/0065 ,  A61K49/0067 ,  A61K49/0093 ,  B82Y15/00 ,  G01N33/532 ,  G01N33/54346 ,  G01N33/5436 ,  G01N33/582 ,  Y10T436/107497

摘要： A composition is disclosed which is capable of being used for detection, comprising an encapsulated noble metal nanocluster. Methods for preparing the encapsulated noble metal nanoclusters, and methods of using the encapsulated noble metal nanoclusters are also disclosed. In certain embodiments, the noble metal nanoclusters are encapsulated by a dendrimer, a peptide, a small organic or inorganic molecule, or an oligonucleotide. The encapsulated noble metal nanoclusters have a characteristic spectral emission, wherein said spectral emission is varied by controlling the nature of the encapsulating material, such as by controlling the size of the nanocluster, the generation of a dendrimer, the incorporation of a functional group, and wherein said emission is used to provide information about a biological state. The emission is selected from the group consisting of nanocluster fluorescence, multiphoton excited nanocluster fluorescence, Stokes or Anti-Stokes Raman emission from the encapsulating material, and second harmonic generation.

摘要翻译： 公开了能够用于检测的组合物，其包含包封的贵金属纳米簇。 还公开了制备包封的贵金属纳米簇的方法，以及使用包封的贵金属纳米团簇的方法。 在某些实施方案中，贵金属纳米簇被树枝状聚合物，肽，小有机或无机分子或寡核苷酸包封。 封装的贵金属纳米团簇具有特征光谱发射，其中通过控制封装材料的性质来改变所述光谱发射，例如通过控制纳米簇的尺寸，树枝状聚合物的产生，官能团的结合，和 其中所述发射用于提供关于生物学状态的信息。 发射选自纳米团簇荧光，多光子激发纳米团簇荧光，来自封装材料的斯托克斯或反斯托克斯拉曼发射以及二次谐波产生。