公开(公告)号：US06221850B1

公开(公告)日：2001-04-24

申请号：US09130616

申请日：1998-08-07

申请人： Robert McKay ,  Nicholas Dean ,  Brett P. Monia ,  Pamela Scott Nero ,  William A. Gaarde

发明人： Robert McKay ,  Nicholas Dean ,  Brett P. Monia ,  Pamela Scott Nero ,  William A. Gaarde

IPC分类号： A61K4800

CPC分类号： C12N15/1137 ,  C07H21/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/334 ,  C12N2310/3515 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase (JNK protein) are provided. Oligonucleotide are herein provided which are specifically hybridizable with nucleic acids encoding JNK1, JNK2 and JNK3, as well as other JNK proteins and specific isoforms thereof. Methods of treating animals suffering from diseases or disorders amenable to therapeutic intervention by modulating the expression of one or more JNK proteins with such oligonucleotide are also provided. Methods for the treatment and diagnosis of diseases or disorders associated with aberrant expression of one or more JNK proteins are also provided. The invention is thus directed to compositions for modulating, diagnostic methods for detecting, and therapeutic methods for inhibiting, the hyperproliferation of cells and formation, development and maintenance of tumors.

摘要翻译： 提供了通过调节编码JunN末端激酶（JNK蛋白）的基因的表达进行治疗的疾病或病症的治疗和诊断的组合物和方法。 本文提供了与编码JNK1，JNK2和JNK3的核酸以及其它JNK蛋白及其特异性同种型特异性杂交的寡核苷酸。 还提供了通过用这种寡核苷酸调节一种或多种JNK蛋白质的表达来治疗患有治疗性干预的疾病或障碍的动物的方法。 还提供了用于治疗和诊断与一种或多种JNK蛋白异常表达相关的疾病或病症的方法。 因此，本发明涉及用于调节，用于检测和用于抑制细胞过度增殖以及形成，发育和维持肿瘤的方法的治疗方法的组合物。