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公开(公告)号：US20080213352A1
公开(公告)日：2008-09-04
申请号：US12073232
申请日：2008-03-03
CPC分类号： A61K31/661 , A61K8/0208 , A61K8/19 , A61K9/0014 , A61K9/1271 , A61K38/28 , A61Q1/02 , A61Q5/02 , A61Q9/00 , A61Q13/00 , A61Q19/007 , A61K2300/00
摘要： Described herein are pharmaceutically acceptable compositions comprising fullerene molecules dispersed in vesicles comprising phosphatidylcholine (PC) phospholipid molecules and non-PC phospholipid molecules suspended in aqueous solution. In preferred embodiments, the phospholipid molecules are substantially uniformly organized into vesicles composed of one or more lipid bilayers and the fullerene molecules are substantially uniformly distributed within the lipid bilayers of the vesicles. Methods of forming these fullerene containing liposomes are also described. Such fullerene containing liposomes provide carriers for delivery of fullerenes for cosmetic, therapeutic, and imaging applications among other uses.
摘要翻译： 本文描述了包含分散在包含磷脂酰胆碱（PC）磷脂分子和悬浮在水溶液中的非PC磷脂分子的囊泡中的富勒烯分子的药学上可接受的组合物。 在优选的实施方案中，磷脂分子基本上均匀地组织成由一个或多个脂质双层组成的囊泡，并且富勒烯分子基本均匀地分布在囊泡的脂质双层内。 还描述了形成这些含富勒烯的脂质体的方法。 这种含富勒烯的脂质体提供用于输送用于化妆品，治疗和成像应用的富勒烯的载体以及其它用途。
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公开(公告)号：US20080214514A1
公开(公告)日：2008-09-04
申请号：US12073231
申请日：2008-03-03
摘要： Described herein are steroid derivatives of fullerene moieties, for example fullerene derivatives in which cholesterol, or a cholesterol moiety, is attached via ester, amide, or ether bonds to one of a variety of “linkers,” e.g., chemical groups including alkyl chains and aromatic groups, which are then connected to the fullerene moiety. The steroid moiety can confers useful solubility in components of biological fluids and/or pharmacologically acceptable carriers and can also affect the biodistribution of the fullerenes which makes the derivatives useful in imaging, diagnosis and the treatment or management of disease or complications of disease states.
摘要翻译： 本文描述的是富勒烯部分的类固醇衍生物，例如富勒烯衍生物，其中胆固醇或胆固醇部分通过酯，酰胺或醚键连接到各种“接头”之一，例如包括烷基链的化学基团和 芳族基团，然后连接到富勒烯部分。 类固醇部分可以赋予生物流体和/或药理学上可接受的载体的组分中有用的溶解性，并且还可以影响富勒烯的生物分布，这使得衍生物可用于成像，诊断和治疗或治疗疾病或疾病状态的并发症。
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