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公开(公告)号：US07976851B2
公开(公告)日：2011-07-12
申请号：US11996379
申请日：2006-07-21
IPC分类号： A61K39/108 , A61K39/00 , A61K39/02
CPC分类号： A61K38/164 , A61L12/14 , A61L27/227 , A61L27/54 , A61L29/048 , A61L29/16
摘要： The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.
摘要翻译： 本发明涉及在生物或非生物表面上预防或抑制生物膜形成的组合物和方法。 组合物包含基于铜绿假单胞菌IV型皮林的C-末端受体结合结构域的肽，其以高亲和力结合非生物表面（例如，钢，塑料），并防止多种铜绿假单胞菌菌株与 表面。 本发明的组合物代表用于生物膜形成的无毒性抑制剂，特别是在非生物表面上，其负责大量有问题的疾病和巨大的经济损失。 本发明的方法可用作改变各种生物医学，纳米技术和生物技术装置或制品的表面的安全和环境友好的手段。
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公开(公告)号：US08454977B2
公开(公告)日：2013-06-04
申请号：US13179058
申请日：2011-07-08
IPC分类号： A61K39/108 , A61K39/00 , A61K39/02
CPC分类号： A61K38/164 , A61L12/14 , A61L27/227 , A61L27/54 , A61L29/048 , A61L29/16
摘要： The present invention relates to a composition, device and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.
摘要翻译： 本发明涉及在生物或非生物表面上预防或抑制生物膜形成的组合物，装置和方法。 组合物包含基于铜绿假单胞菌IV型皮林的C-末端受体结合结构域的肽，其以高亲和力结合非生物表面（例如，钢，塑料），并防止多种铜绿假单胞菌菌株与 表面。 本发明的组合物代表用于生物膜形成的无毒性抑制剂，特别是在非生物表面上，其负责大量有问题的疾病和巨大的经济损失。 本发明的方法可用作改变各种生物医学，纳米技术和生物技术装置或制品的表面的安全和环境友好的手段。
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公开(公告)号：US20120016102A1
公开(公告)日：2012-01-19
申请号：US13179058
申请日：2011-07-08
CPC分类号： A61K38/164 , A61L12/14 , A61L27/227 , A61L27/54 , A61L29/048 , A61L29/16
摘要： The present invention relates to a composition, device and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.
摘要翻译： 本发明涉及在生物或非生物表面上预防或抑制生物膜形成的组合物，装置和方法。 组合物包含基于铜绿假单胞菌IV型皮林的C-末端受体结合结构域的肽，其以高亲和力结合非生物表面（例如，钢，塑料），并防止多种铜绿假单胞菌菌株与 表面。 本发明的组合物代表用于生物膜形成的无毒性抑制剂，特别是在非生物表面上，其负责大量有问题的疾病和巨大的经济损失。 本发明的方法可用作改变各种生物医学，纳米技术和生物技术装置或制品的表面的安全和环境友好的手段。
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公开(公告)号：US20080287367A1
公开(公告)日：2008-11-20
申请号：US11996379
申请日：2006-07-21
CPC分类号： A61K38/164 , A61L12/14 , A61L27/227 , A61L27/54 , A61L29/048 , A61L29/16
摘要： The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.
摘要翻译： 本发明涉及在生物或非生物表面上预防或抑制生物膜形成的组合物和方法。 组合物包含基于铜绿假单胞菌IV型皮林的C-末端受体结合结构域的肽，其以高亲和力结合非生物表面（例如，钢，塑料），并防止多种铜绿假单胞菌菌株与 表面。 本发明的组合物代表用于生物膜形成的无毒性抑制剂，特别是在非生物表面上，其负责大量有问题的疾病和巨大的经济损失。 本发明的方法可用作改变各种生物医学，纳米技术和生物技术装置或制品的表面的安全和环境友好的手段。
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