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公开(公告)号：US07754686B2
公开(公告)日：2010-07-13
申请号：US09944930
申请日：2001-08-31
IPC分类号： A61K38/16 , A61K38/18 , C07K14/435 , C07K14/50
CPC分类号： A61K47/183 , A61K9/0019 , A61K38/1825 , A61K47/18 , A61K47/26
摘要： Stabilized FGF compositions are provided. The compositions comprise FGF or variant thereof and at least one reducing agent in an amount sufficient to inhibit FGF oxidation. Methods for increasing stability of FGF or variant thereof in a liquid or lyophilized composition and for increasing storage stability of such a composition are also provided.
摘要翻译： 提供稳定的FGF组合物。 组合物包含FGF或其变体和至少一种足以抑制FGF氧化的还原剂。 还提供了用于提高液体或冻干组合物中FGF或其变体的稳定性和增加这种组合物的储存稳定性的方法。
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公开(公告)号：US20080293624A1
公开(公告)日：2008-11-27
申请号：US09944930
申请日：2001-08-31
IPC分类号： A61K38/18
CPC分类号： A61K47/183 , A61K9/0019 , A61K38/1825 , A61K47/18 , A61K47/26
摘要： Stabilized FGF compositions are provided. The compositions comprise FGF or variant thereof and at least one reducing agent in an amount sufficient to inhibit FGF oxidation. Methods for increasing stability of FGF or variant thereof in a liquid or lyophilized composition and for increasing storage stability of such a composition are also provided.
摘要翻译： 提供稳定的FGF组合物。 组合物包含FGF或其变体和至少一种足以抑制FGF氧化的还原剂。 还提供了用于提高液体或冻干组合物中FGF或其变体的稳定性和增加这种组合物的储存稳定性的方法。
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3.发明授权Process for preparing microorganisms used for making phenyl acetyl carlinol (PAC) 失效制备用于制备苯乙醇胺（PAC）的微生物的方法
公开(公告)号：US5079145A
公开(公告)日：1992-01-07
申请号：US261010
申请日：1988-10-21
CPC分类号： C12P7/26 , Y10S435/921 , Y10S435/942
摘要： Mutations are induced in a microorganism selected from the species Saccharomyces cerevisiae or from the species Candia flareri. The resulting mutants are cultured in the presence of a fermentation inhibitor, such as acetaldehyde, ephedrine or PAC-dione, to form colonies having resistance to the inhibitor. Cells from the colonies are isolated and tested for yield of phenyl acetyl carbinol (PAC) in a fermentation with benzaldehyde and pyruvate. Yeast cells from the colonies that produce elevated levels of PAC are selected for use in subsequent fermentations. PAC is useful as an intermediate in the preparation of 1-ephedrine and d-pseudoephedrine, two well-known medicinal chemicals.
摘要翻译： 在选自酿酒酵母（Saccharomyces cerevisiae）的种类的微生物或从Candia flareri的种类中诱导突变。 所得突变体在发酵抑制剂如乙醛，麻黄素或PAC-二酮的存在下培养以形成对抑制剂具有抗性的菌落。 在用苯甲醛和丙酮酸的发酵中分离来自菌落的细胞并测试苯乙酰甲醇（PAC）的产率。 选择产生高水平PAC的菌落的酵母细胞用于随后的发酵。 PAC可用作制备1-麻黄碱和d-伪麻黄素的两种着名药用化学品。
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4.发明授权Process for making L-phenyl acetyl carbinol (PAC), microorganisms for use in the process, and a method of preparing the microorganisms 失效制备L-苯基乙酰甲醇（PAC）的方法，用于该方法的微生物以及一种制备微生物的方法
公开(公告)号：US5312742A
公开(公告)日：1994-05-17
申请号：US713982
申请日：1991-06-12
CPC分类号： C12P7/26 , Y10S435/921 , Y10S435/942
摘要： Mutations are induced in a microorganism selected from the species Saccharomyces cerevisiae or from the species Candida flareri. The resulting mutants are cultured in the presence of a fermentation inhibitor, such as acetaldehyde, ephedrine or PAC-dione, to form colonies having resistance to the inhibitor. Cells from the colonies are isolated and tested for yield of phenyl acetyl carbinol (PAC) in a fermentation with benzaldehyde and pyruvate. Yeast cells from the colonies that produce elevated levels of PAC are selected for use in subsequent fermentations. PAC is useful as an intermediate in the preparation of l-ephedrine and d-pseudoephedrine, two well-known medicinal chemicals.
摘要翻译： 在选自酿酒酵母（Saccharomyces cerevisiae）或来自念珠菌（Candida flareri）的微生物中诱导突变。 所得突变体在发酵抑制剂如乙醛，麻黄素或PAC-二酮的存在下培养以形成对抑制剂具有抗性的菌落。 在用苯甲醛和丙酮酸的发酵中分离来自菌落的细胞并测试苯乙酰甲醇（PAC）的产率。 选择产生高水平PAC的菌落的酵母细胞用于随后的发酵。 PAC可用作制备1-麻黄碱和d-伪麻黄碱的两种着名药用化学品。
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