Therapeutic agent for iNOS generating illness
    3.
    发明申请
    Therapeutic agent for iNOS generating illness 审中-公开
    iNOS产生疾病的治疗剂

    公开(公告)号:US20070105780A1

    公开(公告)日:2007-05-10

    申请号:US11268946

    申请日:2005-11-07

    IPC分类号: A61K38/10

    摘要: Treatment of SIRS, sepsis, severe sepsis and septic shock in a mammalian subject in which iNOS is present by decreasing the proteolytic cleavage of the iNOS protein using a protease inhibitor is described.

    摘要翻译: 描述了通过使用蛋白酶抑制剂减少iNOS蛋白质的蛋白水解切割,在存在iNOS的哺乳动物受试者中治疗SIRS,败血症,严重败血症和败血性休克。

    Method of effecting a mammalian model of sepsis, severe sepsis, or septic shock
    4.
    发明申请
    Method of effecting a mammalian model of sepsis, severe sepsis, or septic shock 审中-公开
    影响脓毒症,严重脓毒症或败血性休克的哺乳动物模型的方法

    公开(公告)号:US20070042003A1

    公开(公告)日:2007-02-22

    申请号:US11208143

    申请日:2005-08-19

    IPC分类号: A61K39/02 A61K31/739

    CPC分类号: A61K31/739

    摘要: A method of effecting a model of sepsis, severe sepsis, or septic shock in a mammalian subject which utilizes the step of introducing particulate or vesicle associated iNOS into the body of the mammalian subject. Prior to or during such introduction, an innate immune system activator may be introduced into the body of the mammalian subject. Other substances may also be introduced into the mammalian subject prior to or during the introduction of the particulate or vesicle associated iNOS in order to observe the physiological consequences on the mammalian subject.

    摘要翻译: 在哺乳动物受试者中实施败血症,严重败血症或败血性休克模型的方法,其利用将颗粒或囊泡相关联的iNOS引入哺乳动物受试者体内的步骤。 在此之前或期间,可将先天免疫系统激活剂引入哺乳动物受试者的体内。 在引入颗粒或囊泡相关联的iNOS之前或期间,也可以将其它物质引入哺乳动物受试者中,以观察对哺乳动物受试者的生理后果。