公开(公告)号：US20130023055A1

公开(公告)日：2013-01-24

申请号：US13630665

申请日：2012-09-28

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Hans-Peter Josel ,  Hans-Joachim Kytzia ,  Matthias Muecke

IPC: G01N21/75

CPC classification number: G01N33/84 ,  C07C229/18

Abstract: Reagents and methods for determination of calcium within a sample. Specific embodiments include a reagent for determination of calcium comprising a mono-nitro substituted BAPTA-type chelator (BAPTA=1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid). Methods for accurate determination of calcium in a sample, such as a blood, whole blood, plasma or serum or any other aqueous liquid sample including cerebrospinal fluid, lymph, salivary juice or urine. Embodiments are also useful for clinical diagnoses.

Abstract translation: 用于测定样品中钙的试剂和方法。 具体实施方案包括用于测定钙的试剂，其包含单硝基取代的BAPTA型螯合剂（BAPTA = 1,2-双（2-氨基苯氧基）乙烷-N，N，N'，N'-四乙酸）。 用于精确测定样品（例如血液，全血，血浆或血清）或任何其它含水液体样品（包括脑脊液，淋巴，唾液汁或尿液）的钙的方法。 实施方式也可用于临床诊断。

公开(公告)号：US08962338B2

公开(公告)日：2015-02-24

申请号：US13630665

申请日：2012-09-28

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Hans-Peter Josel ,  Hans-Joachim Kytzia ,  Matthias Muecke

IPC: G01N21/75 ,  G01N33/84 ,  C07C229/18

CPC classification number: G01N33/84 ,  C07C229/18

Abstract: Reagents and methods for determination of calcium within a sample. Specific embodiments include a reagent for determination of calcium comprising a mono-nitro substituted BAPTA-type chelator (BAPTA=1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid). Methods for accurate determination of calcium in a sample, such as a blood, whole blood, plasma or serum or any other aqueous liquid sample including cerebrospinal fluid, lymph, salivary juice or urine. Embodiments are also useful for clinical diagnoses.

Abstract translation: 用于测定样品中钙的试剂和方法。 具体实施方案包括用于测定钙的试剂，其包含单硝基取代的BAPTA型螯合剂（BAPTA = 1,2-双（2-氨基苯氧基）乙烷-N，N，N'，N'-四乙酸）。 用于精确测定样品（例如血液，全血，血浆或血清）或任何其它含水液体样品（包括脑脊液，淋巴，唾液汁或尿液）的钙的方法。 实施方式也可用于临床诊断。