-
公开(公告)号：US20210009993A1
公开(公告)日：2021-01-14
申请号：US17015719
申请日：2020-09-09
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Kroner , Michael Schraeml , Sarah Liedke
Abstract: The present invention relates to a novel method of generating libraries of polynucleotides encoding a framework region and at least one adjacent complementarity determining region (CDR) of an antibody of interest. These libraries are suitable for use in affinity maturation procedures in order to obtain maturated antibodies with improved characteristics compared to the parent antibody.
-
公开(公告)号：US12275778B2
公开(公告)日：2025-04-15
申请号：US17015662
申请日：2020-09-09
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Kroner , Michael Schraeml , Sarah Liedke
Abstract: The present invention relates to improved variant monoclonal antibodies binding to cardiac troponin T and having a better KD than the monoclonal antibody 12.1A11.11-7, produced by hybridoma clone 7.1 A 12.2-22 (ECACC 89060901) as deposited with European Collection of Animal Cell Cultures, GB.
-
公开(公告)号：US20210009668A1
公开(公告)日：2021-01-14
申请号：US17015662
申请日：2020-09-09
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Kroner , Michael Schraeml , Sarah Liedke
Abstract: The present invention relates to improved variant monoclonal antibodies binding to cardiac troponin T and having a better KD than the monoclonal antibody 12.1A11.11-7, produced by hybridoma clone 7.1 A 12.2-22 (ECACC 89060901) as deposited with European Collection of Animal Cell Cultures, GB. 5
-
-
Search Results
3
records
(took 0.011 seconds)
