公开(公告)号：US20160146836A1

公开(公告)日：2016-05-26

申请号：US15007840

申请日：2016-01-27

申请人： Roche Diagnostics Operations, Inc. ,  The Governing Council of the University of Toronto

发明人： Ursula-Henrike Wienhues-Thelen ,  Georg Hess ,  Dirk Block ,  Hendrik Huedig ,  Andrew Emili ,  Anthony Gramolini ,  Peter Liu ,  David MacLennan ,  Sara Arab

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/6887 ,  G01N2333/4712 ,  G01N2800/325

摘要： The invention relates to a method for assessing heart failure in vitro comprising the steps of measuring in a sample the concentration of the marker CRYAB, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure selected from the group consisting of a natriuretic peptide marker, a cardiac troponin marker, and a marker of inflammation, and of assessing heart failure by comparing the concentration determined in for CRYAB and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of CRYAB as a marker protein in the assessment of heart failure, a marker combination comprising CRYAB and a kit for measuring CRYAB.

摘要翻译： 本发明涉及一种用于评估体外心脏衰竭的方法，包括以下步骤：在样品中测量标记物CRYAB的浓度，任选地在样品中测量一种或多种其它心力衰竭标志物的浓度，该浓度选自 由利尿钠肽标记物，心肌肌钙蛋白标志物和炎症标志物组成的组，并且通过将对于CRYAB测定的浓度与对任选的一种或多种其它标记物测定的浓度与浓度 的这种标记物或这些标记物在参考群体中建立。 还公开了CRYAB作为评估心力衰竭的标记蛋白的用途，包括CRYAB的标记组合和用于测量CRYAB的试剂盒。

公开(公告)号：US20140193845A1

公开(公告)日：2014-07-10

申请号：US14180384

申请日：2014-02-14

申请人： The Governing Council of the University of Toronto ,  Roche Diagnostics Operations, Inc.

发明人： Ursula-Henrike Wienhues-Thelen ,  Sara Arab ,  Dirk Block ,  Andrew Emili ,  Anthony Gramolini ,  Georg Hess ,  Hendrik Huedig ,  Peter Liu ,  David MacLennan

IPC分类号： G01N33/566

CPC分类号： G01N33/566 ,  G01N33/6893 ,  G01N2800/325

摘要： Disclosed is a method for assessing heart failure in vitro including the steps of measuring in a sample the concentration of the marker SFRP-3, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration determined in for SFRP-3 and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of SFRP-3 as a marker protein in the assessment of heart failure, a marker combination comprising SFRP-3 and a kit for measuring SFRP-3.

摘要翻译： 公开了一种用于评估体外心脏衰竭的方法，包括以下步骤：在样品中测量标记物SFRP-3的浓度，任选地在样品中测量一种或多种其他心力衰竭标志物的浓度，以及 通过比较在SFRP-3中确定的浓度和为任选的一种或多种其它标记确定的浓度与在参考群体中确定的该标志物或这些标记物的浓度进行比较来评估心力衰竭。 还公开了在评估心力衰竭中使用SFRP-3作为标记蛋白，包括SFRP-3的标记物组合和用于测量SFRP-3的试剂盒。