公开(公告)号：US20130225570A1

公开(公告)日：2013-08-29

申请号：US13866212

申请日：2013-04-19

申请人： Roche Palo Alto LLC

发明人： Chris Allen Broka ,  David Scott Carter ,  Michael Patrick Dillon ,  Anthony P.D.W. Ford ,  Ronald Charles Hawley ,  Alam Jahangir ,  Amy Geraldine Moore ,  Daniel Warren Parish

IPC分类号： A61K31/505 ,  A61K31/538 ,  A61K31/506

CPC分类号： A61K31/506 ,  A61K31/505 ,  A61K31/513 ,  A61K31/538 ,  Y10S514/826

摘要： Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的呼吸道和胃肠道疾病的方法，所述方法包括向有需要的受试者施用有效量的式（I）化合物或其药学上可接受的盐， 其中D，X，Y，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。

公开(公告)号：US20160271131A1

公开(公告)日：2016-09-22

申请号：US15170666

申请日：2016-06-01

申请人： Roche Palo Alto LLC

发明人： Chris Allen Broka ,  David Scott Carter ,  Michael Patrick Dillon ,  Anthony P.D.W. Ford ,  Ronald Charles Hawley ,  Alam Jahangir ,  Amy Geraldine Moore ,  Daniel Warren Parish

IPC分类号： A61K31/506 ,  A61K31/538 ,  A61K31/505

CPC分类号： A61K31/506 ,  A61K31/505 ,  A61K31/513 ,  A61K31/538 ,  Y10S514/826

摘要： Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.