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公开(公告)号：US07194307B2
公开(公告)日：2007-03-20
申请号：US10744952
申请日：2003-12-22
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3684
摘要： An implantable device for delivering cardiac pacing therapy in order to improve cardiac function is programmed to allow some amount of intrinsic activity to occur without otherwise the disturbing the pacing algorithm used to deliver therapy. Intrinsic cardiac cycles utilize the heart's native conduction system and thus serve to prevent the atrophy which may otherwise result from continuous pacing.
摘要翻译： 用于递送心脏起搏治疗以改善心脏功能的可植入装置被编程为允许发生一定量的内在活动，而无需另外打扰用于递送治疗的起搏算法。 内在心脏周期利用心脏的天然传导系统，从而用于预防由连续起搏引起的萎缩。
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公开(公告)号：US07627373B2
公开(公告)日：2009-12-01
申请号：US10723258
申请日：2003-11-25
IPC分类号： A61N1/00
CPC分类号： A61N1/362
摘要： A method for cell and electrical therapy of living tissue including administration of exogenous cells into a region of injured tissue and application of electrical energy. In one application the combined cell and electrical therapy is applied in vivo to damaged heart tissue. In such applications, minimally invasive procedures are used to apply the cell therapy and the electrical therapy is provided via an implantable pulse generator. In one application an implantable pacemaker is used in the VDD mode with an atrioventricular delay kept relatively short when compared to the intrinsic atrioventricular delay.
摘要翻译： 一种用于生物组织的细胞和电疗法的方法，包括将外源细胞施用到损伤组织的区域中并施加电能。 在一个应用中，组合的细胞和电疗法在体内应用于损伤的心脏组织。 在这样的应用中，使用微创手术来应用细胞治疗，并且通过可植入脉冲发生器提供电疗法。 在一个应用中，可以使用植入式起搏器进行VDD模式，与内在房室延迟相比，房室延迟保持相对较短。
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公开(公告)号：US08369948B2
公开(公告)日：2013-02-05
申请号：US13279493
申请日：2011-10-24
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/365 , A61N1/36542 , A61N1/36585 , A61N1/368
摘要： An apparatus for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.
摘要翻译： 用电刺激治疗逆转心室重构的装置。 通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。 随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。
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4.发明授权公开(公告)号：US06640135B1
公开(公告)日：2003-10-28
申请号：US09544363
申请日：2000-04-06
IPC分类号： A61N1368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627
摘要： A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.
摘要翻译： 一种心脏电刺激装置及其操作方法，其中刺激脉冲分布在固定在心肌不同部位的多个电极之间，以便通过在单个部位重复起搏而引起的心肌肥大和/或增加心肌收缩力 。 为了空间和时间地分布刺激，脉冲在单个心动周期期间通过可切换的脉冲输出配置递送，每个配置包括一个或多个电极固定在心肌中的不同部位。
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公开(公告)号：US20120041504A1
公开(公告)日：2012-02-16
申请号：US13279493
申请日：2011-10-24
CPC分类号： A61N1/3627 , A61N1/365 , A61N1/36542 , A61N1/36585 , A61N1/368
摘要： An apparatus for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.
摘要翻译： 用电刺激治疗逆转心室重构的装置。 通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。 随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。
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公开(公告)号：US08046066B2
公开(公告)日：2011-10-25
申请号：US12484882
申请日：2009-06-15
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/365 , A61N1/36542 , A61N1/36585 , A61N1/368
摘要： An apparatus for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.
摘要翻译： 用电刺激治疗逆转心室重构的装置。 通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。 随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。
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7.发明授权公开(公告)号：US07292887B2
公开(公告)日：2007-11-06
申请号：US10634232
申请日：2003-08-05
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627
摘要： A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.
摘要翻译： 一种心脏电刺激装置及其操作方法，其中刺激脉冲分布在固定在心肌不同部位的多个电极之间，以便通过在单个部位重复起搏而引起的心肌肥大和/或增加心肌收缩力 。 为了空间和时间地分布刺激，脉冲在单个心动周期期间通过可切换的脉冲输出配置递送，每个配置包括一个或多个电极固定在心肌中的不同部位。
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8.发明授权公开(公告)号：US08090442B2
公开(公告)日：2012-01-03
申请号：US11931718
申请日：2007-10-31
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627
摘要： A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.
摘要翻译： 一种心脏电刺激装置及其操作方法，其中刺激脉冲分布在固定在心肌不同部位的多个电极之间，以便通过在单个部位重复起搏而引起的心肌肥大和/或增加心肌收缩力 。 为了空间和时间地分布刺激，脉冲在单个心动周期期间通过可切换的脉冲输出配置递送，每个配置包括一个或多个电极固定在心肌中的不同部位。
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9.发明授权Apparatus for spatially and temporally distributing cardiac electrical stimulation 有权用于空间和时间分布心脏电刺激的装置公开(公告)号：US08560067B2
公开(公告)日：2013-10-15
申请号：US11931779
申请日：2007-10-31
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627
摘要： A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.
摘要翻译： 一种心脏电刺激装置及其操作方法，其中刺激脉冲分布在固定在心肌不同部位的多个电极之间，以便通过在单个部位重复起搏而引起的心肌肥大和/或增加心肌收缩力 。 为了空间和时间地分布刺激，脉冲在单个心动周期期间通过可切换的脉冲输出配置递送，每个配置包括一个或多个电极固定在心肌中的不同部位。
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10.发明申请公开(公告)号：US20090254141A1
公开(公告)日：2009-10-08
申请号：US12484882
申请日：2009-06-15
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/365 , A61N1/36542 , A61N1/36585 , A61N1/368
摘要： An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.
摘要翻译： 用电刺激治疗逆转心室重构的装置和方法。 通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。 随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。
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