公开(公告)号：US5215971A

公开(公告)日：1993-06-01

申请号：US726738

申请日：1991-07-02

申请人： Roelf Datema ,  Kristina B. Gotthammar ,  Karl N. G. Johansson ,  Zsuzsanna M. I. Kovacs ,  Bjorn G. Lindborg ,  Goran B. Stening ,  Bo F. berg

发明人： Roelf Datema ,  Kristina B. Gotthammar ,  Karl N. G. Johansson ,  Zsuzsanna M. I. Kovacs ,  Bjorn G. Lindborg ,  Goran B. Stening ,  Bo F. berg

IPC分类号： C07H19/06

CPC分类号： A61K31/70 ,  C07H19/06 ,  Y10S514/894

摘要： Use of a compound of the formula ##STR1## wherein A is .beta.-2'-deoxy-D-ribofuranosyl or .beta.-D-arabinofuranosyl;R.sup.1 is hydroxy or amino;R.sup.2 is cycloalkyl or alkyl-substituted cycloalkyl containing 1-5 carbon atoms; saturated or unsaturated, straight or branched alkyl containing 1-5 carbon atoms which may be unsubstituted or substituted with halogen, hydroxy, mercapto, trifluoroalkyl or difluoroalkyl containing 1-3 carbon atoms, phenoxy or alkoxy containing 1-3 carbon atoms; phenyl or phenylalkyl containing 1-3 carbon atoms in the alkyl part, or a physiologically acceptable salt thereof,for manufacture of a medicament for therapeutic or prophylactic control or treatment of retrovirus, especially HIV, or hepatitis B virus infections in animal and man and to a method of such treatment.

摘要翻译： 使用下式的化合物其中A为β-2'-脱氧-D-呋喃核糖基或β-D-阿拉伯呋喃糖基; R1是羟基或氨基; R2是环烷基或含1-5个碳原子的烷基取代的环烷基; 含有1-5个碳原子的饱和或不饱和的直链或支链烷基，其可以是未取代的或被含有1-3个碳原子的卤素，羟基，巯基，三氟烷基或二氟烷基取代，苯氧基或含有1-3个碳原子的烷氧基; 在烷基部分含有1-3个碳原子的苯基或苯基烷基或其生理上可接受的盐，用于制备用于治疗或预防性控制或治疗动物和人类的逆转录病毒，特别是HIV或乙型肝炎病毒感染的药物，以及 这种治疗方法。

公开(公告)号：US5036071A

公开(公告)日：1991-07-30

申请号：US147051

申请日：1988-01-22

申请人： Karl N. G. Johansson ,  Zsuzsanna M. I. Kovacs ,  Bjorn G. Lindborg ,  Goran B. Stening

发明人： Karl N. G. Johansson ,  Zsuzsanna M. I. Kovacs ,  Bjorn G. Lindborg ,  Goran B. Stening

IPC分类号： C07D473/32 ,  A61K31/52 ,  A61P31/12 ,  A61P31/22 ,  A61P35/00 ,  C07D473/00

CPC分类号： C07D473/00

摘要： Antivirally active compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or hydroxymethyl;R.sub.2 is hydrogen, hydroxy or hydroxymethyl;R.sub.3 is hydrogen; or R.sub.1 and R.sub.3 together constitute an additional carbon-carbon bond;with the proviso that when R.sub.1 is hydrogen then R.sub.2 is hydroxy or hydroxymethyl, that when R.sub.1 is hydroxymethyl then R.sub.2 is hydrogen and that when R.sub.2 is hydroxy then R.sub.1 is hydrogen; and physiologically acceptable salts; geometric or optical isomers thereof; processes for preparation of said compounds, pharmaceutical preparations containing the compounds, methods for treatment of virus infections and medical use of the compounds.

摘要翻译： 下式的抗病毒活性化合物其中R 1是氢或羟甲基; R2是氢，羟基或羟甲基; R3是氢; 或R 1和R 3一起构成额外的碳 - 碳键; 条件是当R 1为氢时，R 2为羟基或羟甲基，当R 1为羟甲基时，则R 2为氢，当R 2为羟基时，R 1为氢; 和生理上可接受的盐; 几何或光学异构体; 所述化合物的制备方法，含有化合物的药物制剂，治疗病毒感染的方法和化合物的医疗用途。

公开(公告)号：US4495190A

公开(公告)日：1985-01-22

申请号：US436522

申请日：1982-10-25

申请人： Curt-Erik Hagberg ,  Karl N. Johansson ,  Zsuzsanna M. I. Kovacs ,  Goran B. Stening

发明人： Curt-Erik Hagberg ,  Karl N. Johansson ,  Zsuzsanna M. I. Kovacs ,  Goran B. Stening

IPC分类号： C07D473/18 ,  A61K31/522 ,  A61P31/12 ,  C07D307/33 ,  C07D473/00 ,  A61K31/52

CPC分类号： C07D307/33 ,  C07D473/00

摘要： Novel antiviral compounds of the formula ##STR1## wherein each of R.sub.1 and R.sub.2, which are the same or different is hydrogen, hydroxy or fluoro; provided that R.sub.1 or R.sub.2 is hydrogen when R.sub.1 and R.sub.2 are different, and provided that R.sub.1 and R.sub.2 are hydroxy or fluoro when R.sub.1 and R.sub.2 are the same; or a physiologically acceptable salt or an optical isomer thereof, methods for their preparation, pharmaceutical preparations containing the compounds, and methods for the treatment of virus infections and other diseases caused by viruses.

摘要翻译： 式（IMAGE）的新型抗病毒化合物，其中相同或不同的R 1和R 2各自为氢，羟基或氟; 条件是当R 1和R 2不同时，R 1或R 2为氢，并且当R 1和R 2相同时，R 1和R 2为羟基或氟; 或其生理上可接受的盐或其旋光异构体，其制备方法，含有该化合物的药物制剂，以及用于治疗由病毒引起的病毒感染和其它疾病的方法。