公开(公告)号：US07115662B2

公开(公告)日：2006-10-03

申请号：US10728244

申请日：2003-12-04

申请人： Roger A Fujimoto ,  Leslie W McQuire ,  Benjamin B Mugrage ,  John H Van Duzer ,  Daqiang Xu

发明人： Roger A Fujimoto ,  Leslie W McQuire ,  Benjamin B Mugrage ,  John H Van Duzer ,  Daqiang Xu

IPC分类号： A61K31/235

CPC分类号： C07C229/42

摘要： Disclosed are the compounds of formula I wherein R is methyl or ethyl; R1 is chloro or fluoro; R2 is hydrogen or fluoro; R3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R4 is hydrogen or fluoro; and R5 is chloro, fluoro, trifluoromethyl or methyl; and pharmaceutically acceptable salts thereof, as selective COX-2 cyclooxygenase inhibitors; and pharmaceutically acceptable prodrug esters thereof.

摘要翻译： 公开了式I的化合物，其中R是甲基或乙基; R 1是氯或氟; R 2是氢或氟; R 3是氢，氟，氯，甲基，乙基，甲氧基，乙氧基或羟基; R 4是氢或氟; 和R 5是氯，氟，三氟甲基或甲基; 作为选择性COX-2环加氧酶抑制剂; 及其药学上可接受的前药酯。