公开(公告)号：US20130137628A1

公开(公告)日：2013-05-30

申请号：US13697251

申请日：2011-05-11

申请人： Roger S. Newton ,  Rai Ajit K. Srivastava ,  Timothy R. Hurley ,  Clay Cramer ,  Sergey V. Filippov ,  Stephen L. Pinkosky

发明人： Roger S. Newton ,  Rai Ajit K. Srivastava ,  Timothy R. Hurley ,  Clay Cramer ,  Sergey V. Filippov ,  Stephen L. Pinkosky

IPC分类号： C07K14/775

CPC分类号： C07K14/775 ,  A61K38/00

摘要： An isolated oxidation-resistant ApoA1 variant dimer includes a first oxidation-resistant ApoA1 variant polypeptide monomer and a second oxidation-resistant ApoA1 variant polypeptide monomer, wherein at least one of the first and the second monomers comprises at least one amino acid substitution of a tryptophan residue for an oxidation resistant amino acid, or a functional fragment or variant thereof. Methods for treating a disease or disorder comprises administering to a subject in need thereof, a therapeutically effective amount of an isolated oxidation-resistant ApoA1 variant dimer, an oxidation-resistant ApoA1 variant monomer, an oxidation-resistant ApoA1 monomer-lipid complex, a lipid complexed oxidation-resistant ApoA1 variant monomer, a lipid complexed oxidation-resistant ApoA1 variant dimer, or combinations thereof to the subject to enhance cholesterol efflux activity in the presence of an oxidant.

摘要翻译： 分离的抗氧化ApoA1变体二聚体包括第一抗氧化ApoA1变体多肽单体和第二抗氧化ApoA1变体多肽单体，其中第一和第二单体中的至少一个包含至少一个色氨酸的氨基酸取代 用于抗氧化氨基酸的残基或其功能片段或变体。 用于治疗疾病或病症的方法包括向有需要的受试者施用治疗有效量的分离的抗氧化ApoA1变体二聚体，抗氧化ApoA1变体单体，抗氧化ApoA1单体 - 脂质复合物，脂质 复合抗氧化ApoA1变体单体，脂质复合抗氧化ApoA1变体二聚体或其组合，以增强氧化剂存在下的胆固醇流出活性。