公开(公告)号：US07267822B2

公开(公告)日：2007-09-11

申请号：US10780321

申请日：2004-02-17

申请人： Roland Buelow ,  Gèrard Grassy ,  Bernard Calas

发明人： Roland Buelow ,  Gèrard Grassy ,  Bernard Calas

IPC分类号： A61K38/00 ,  A61K38/03 ,  A61K47/00 ,  A61K47/10 ,  A61K47/18 ,  A61K31/045 ,  C07K7/06

CPC分类号： C07K7/06 ,  A61K38/00

摘要： Novel oligonucleotides comprising a sequence derived by a computer program are provided for inhibiting cytotoxic activity of lymphocytic cells, inhibiting production of inflammatory cytokines and inflammatory responses associated with those cytokines, inhibiting the activity of heme-containing enzymes and delaying the onset of an autoimmune disease. By combining the subject compositions with mixtures of cells comprising lymphocytic cells and cells which would otherwise activate the lymphocytic cells, lysis of the target cells can be substantially inhibited. The oligopeptides may be joined to a variety of other groups or compounds for varying the activity of the subject composition. The subject compositions may be administered by any convenient means to inhibit lymphocytic attack on tissue, particularly involved with xenogeneic or allogeneic transplants or to inhibit the production of inflammatory cytokines and inflammatory responses associated therewith. The subject compositions may also be used in the inhibition of the activity of heme-containing enzymes.

摘要翻译： 提供包含通过计算机程序导出的序列的新型寡核苷酸用于抑制淋巴细胞的细胞毒活性，抑制炎症细胞因子的产生和与这些细胞因子相关的炎性反应，抑制含血红素酶的活性并延迟自身免疫性疾病的发作。 通过将主题组合物与包含淋巴细胞的细胞和否则将激活淋巴细胞的细胞的混合物组合，可以基本上抑制靶细胞的裂解。 寡肽可以连接到各种其它基团或化合物以改变主题组合物的活性。 主题组合物可以通过任何方便的手段来施用，以抑制对组织的淋巴细胞侵袭，特别是涉及异种或同种异体移植物或抑制炎性细胞因子的产生和与之相关的炎性反应。 主题组合物也可用于抑制含血红素酶的活性。

公开(公告)号：US06696545B1

公开(公告)日：2004-02-24

申请号：US09028083

申请日：1998-02-23

申请人： Roland Buelow ,  Gèrard Grassy ,  Bernard Calas

发明人： Roland Buelow ,  Gèrard Grassy ,  Bernard Calas

IPC分类号： A61K3800

CPC分类号： C07K7/06 ,  A61K38/00

摘要： Novel oligopeptides comprising a sequence derived by a computer program are provided for use in inhibiting cytotoxic activity of lymphocytic cells, inhibiting the production of inflammatory cytokines and inflammatory responses associated with those cytokines, inhibiting the activity of heme-containing enzymes and delaying the onset of an autoimmune disease in a mammal at risk of developing the disease. By combining the subject compositions with mixtures of cells comprising lymphocytic cells and cells which would otherwise activate the lymphocytic cells, lysis of the target cells can be substantially inhibited. The oligopeptides may be joined to a wide variety of other groups or compounds for varying the activity of the subject compositions. The subject compositions may be administered by any convenient means to a host to inhibit lymphocytic attack on tissue, particularly involved with xenogeneic or allogeneic transplants or to inhibit the production of inflammatory cytokines and inflammatory responses associated therewith. The subject compositions may also be used in the inhibition of the activity of heme-containing enzymes.

摘要翻译： 提供了包含通过计算机程序导出的序列的新型寡肽，用于抑制淋巴细胞的细胞毒性活性，抑制炎症细胞因子的产生和与那些细胞因子相关的炎症反应，抑制含血红素酶的活性并延迟起始 在发生该疾病风险的哺乳动物中的自身免疫性疾病。 通过将主题组合物与包含淋巴细胞的细胞和否则将激活淋巴细胞的细胞的混合物组合，可以基本上抑制靶细胞的裂解。 寡肽可以连接到各种各样的其它基团或化合物以改变主题组合物的活性。 主题组合物可以通过任何方便的方式施用于宿主以抑制对组织的淋巴细胞侵袭，特别是涉及异种或同种异体移植物或抑制与之相关的炎性细胞因子和炎性反应的产生。 主题组合物也可用于抑制含血红素酶的活性。