公开(公告)号：US4482717A

公开(公告)日：1984-11-13

申请号：US493505

申请日：1983-05-11

Applicant: Rolf Dinkel ,  Hilmar Roedel ,  James I. Grayson

Inventor： Rolf Dinkel ,  Hilmar Roedel ,  James I. Grayson

IPC: C07D213/10 ,  C07D213/08

CPC classification number: C07D213/10

Abstract: Method for the production of 3-picoline wherein a first educt, consisting of at least one acetaldehydeacetal with or without acetaldehyde and/or crotonaldehyde, is reacted with a second educt, consisting of at least one formaldehydeacetal and/or hexamethylenetetramine with or without formaldehyde, in a liquid, aqueous phase at a temperature of 180.degree. to 280.degree. C. in a closed vessel. The reaction is conducted in the presence of ammonia and/or ammonium ions. The reaction is also conducted in the presence of an anion or anions of an inorganic and/or organic acid or acids, which at 20.degree. C. have an acid dissociation constant of 10.sup.6 to 10.sup.-12.

Abstract translation: 用于生产3-甲基吡啶的方法，其中由至少一种具有或不具有乙醛和/或巴豆醛的乙醛缩合物组成的第一流出物与由具有或不具有甲醛的至少一种甲醛缩醛和/或六亚甲基四胺组成的第二离子流反应， 在180℃至280℃的液体水相中，在密闭容器中。 反应在氨和/或铵离子的存在下进行。 反应也在无机和/或有机酸或酸的阴离子或阴离子存在下进行，其在20℃具有106至10-12的酸解离常数。

公开(公告)号：US4481361A

公开(公告)日：1984-11-06

申请号：US493506

申请日：1983-05-11

Applicant: Rolf Dinkel ,  Hilmar Roedel ,  James I. Grayson

Inventor： Rolf Dinkel ,  Hilmar Roedel ,  James I. Grayson

IPC: C07D213/10 ,  C07D213/08

CPC classification number: C07D213/10

Abstract: Process for the production of 3-picoline wherein a first educt, consisting of acetaldehyde and/or at least one acetaldehydeacetal and/or crotonaldehyde, is reacted with a second educt, consisting of formaldehyde and/or at least one formaldehydeacetal and/or hexamethylenetetramine, in a liquid, aqueous phase at a temperature of 180.degree. to 280.degree. C. in a closed vessel. The reaction is conducted in the presence of ammonia and/or ammonium ions. The reaction is also conducted in the presence of at least one water-soluble alkali metal salt of an inorganic and/or organic acid or acids which provides an anion or anions of an inorganic and/or organic acid or acids, which at 20.degree. C. have an acid dissociation constant of 10.sup.6 to 10.sup.-12.

Abstract translation: 用于生产3-甲基吡啶的方法，其中由乙醛和/或至少一种乙醛缩醛和/或巴豆醛组成的第一次流出物与由甲醛和/或至少一种甲醛缩醛和/或六亚甲基四胺组成的第二次流出物反应， 在180℃至280℃的液体水相中，在密闭容器中。 反应在氨和/或铵离子的存在下进行。 该反应还在至少一种无机和/或有机酸的水溶性碱金属盐或酸的存在下进行，该酸提供无机和/或有机酸或酸的阴离子或阴离子，其在20℃ 具有106至10-12的酸解离常数。

公开(公告)号：US4421921A

公开(公告)日：1983-12-20

申请号：US415835

申请日：1982-09-08

Applicant: James I. Grayson ,  Rolf Dinkel

Inventor： James I. Grayson ,  Rolf Dinkel

IPC: C07D213/12 ,  C07D213/09 ,  C07D213/10

CPC classification number: C07D213/12

Abstract: Process for the production of 3-picoline. Acrolein or a mixture of acrolein and formaldehyde is reacted in a liquid aqueous phase at a temperature of 180.degree. to 280.degree. C. in a closed vessel. Ammonia and/or ammonium ions, and anions of an inorganic or organic acid, which has an acid dissociation constant of 10.sup.6 to 10.sup.-12, at 20.degree. C., are also present.

Abstract translation: 3-甲基吡啶生产工艺。 丙烯醛或丙烯醛和甲醛的混合物在液体水相中在180-280℃的温度下在密闭容器中反应。 还存在氨和/或铵离子以及在20℃下具有106至10-12的酸解离常数的无机或有机酸的阴离子。

公开(公告)号：US4370481A

公开(公告)日：1983-01-25

申请号：US357626

申请日：1982-03-12

Applicant: Rolf Dinkel

Inventor： Rolf Dinkel

IPC: C07D213/10 ,  C07D213/12 ,  C07D213/08

CPC classification number: C07D213/12 ,  C07D213/10

Abstract: Process for the production of 3-picoline. A first educt consisting of acetaldehyde and/or acetaldehydeacetals and/or crotonaldehyde is reacted with a second educt consisting of formaldehyde and/or formaldehydeacetals and/or hexamethylenetetramine. The reaction is conducted in a liquid, aqueous phase at a temperature of 180.degree. to 280.degree. C. in a closed vessel in the presence of an amide of a carboxylic acid.

Abstract translation: 3-甲基吡啶生产工艺。 由乙醛和/或乙醛缩醛和/或巴豆醛组成的第一次喷射与由甲醛和/或甲醛缩醛和/或六亚甲基四胺组成的第二次喷射反应。 该反应在液体的水相中，在180℃至280℃的温度下，在密闭容器中，在羧酸的酰胺存在下进行。

公开(公告)号：US4337342A

公开(公告)日：1982-06-29

申请号：US263042

申请日：1981-05-12

Applicant: Rolf Dinkel

Inventor： Rolf Dinkel

IPC: C07D213/08 ,  C07D213/09 ,  C07D213/10 ,  C07D213/12

CPC classification number: C07D213/08 ,  C07D213/10 ,  C07D213/12

Abstract: A process for the preparation of 3-picoline wherein a mixture acetaldehyde and/or crotonaldehyde with formaldehyde is reacted in the presence of an ammonium salt at a temperature of 180.degree. to 280.degree. C. in a closed vessel. The mixture is in the liquid phase.

Abstract translation: 一种制备3-甲基吡啶的方法，其中乙醛和/或巴豆醛与甲醛的混合物在铵盐存在下在180-280℃的温度下在密闭容器中反应。 混合物处于液相。