专利检索 ap:("Ronald Kuehne" OR "Hartmut Oschkinat" OR "Christoph Brockmann" OR "Hans-Guenther Schmalz" OR "Jan Zaminer") AND inv:"Jan Zaminer" 第 1 页

1.

发明授权
Structural mimetics of proline-rich peptides and the pharmaceutical use thereof 有权
标题翻译：富含脯氨酸的肽的结构模拟物及其药物用途

公开(公告)号：US08242105B2

公开(公告)日：2012-08-14

申请号：US12442681

申请日：2007-09-25

申请人： Ronald Kuehne , Hartmut Oschkinat , Christoph Brockmann , Hans-Guenther Schmalz , Jan Zaminer

发明人： Ronald Kuehne , Hartmut Oschkinat , Christoph Brockmann , Hans-Guenther Schmalz , Jan Zaminer

IPC分类号： A61K31/55 , C07D223/00

CPC分类号： C07D487/14

摘要： The invention relates to compounds of general formula (I), which can be used particularly as structural mimetics of proline-rich peptides and are therefore capable of binding PRM binding domains (proline-rich motif binding domains) of proteins. The invention also relates to the use of said compounds as pharmaceutical active agents and the use of these pharmaceutical active agents for treating bacterial diseases, neurodegenerative diseases and tumors.

摘要翻译： 本发明涉及通式（I）的化合物，其可特别用作富含脯氨酸的肽的结构模拟物，因此能够结合蛋白质的PRM结合结构域（富含脯氨酸的基序结合结构域）。本发明还涉及所述化合物作为药物活性剂的用途以及这些药物活性剂用于治疗细菌性疾病，神经变性疾病和肿瘤的用途。