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公开(公告)号:US20050119338A1
公开(公告)日:2005-06-02
申请号:US10498024
申请日:2002-12-12
IPC分类号: C07D493/04 , A61K31/34 , A61K31/365 , A61K31/4164 , A61K31/427 , A61K31/496 , A61K31/635 , A61K45/00 , A61P31/12 , A61P31/18 , A61P43/00 , A61K31/343
CPC分类号: A61K31/635 , A61K2300/00
摘要: The present invention relates to a method for improving the pharmacokinetics of hexahydrofuro[2,3-b]furanyl containing HIV protease inhibitors comprising administering to a human in need thereof a combination of a therapeutically effective amount of a hexahydrofuro[2,3-b]furanyl containing HIV protease inhibitor, and a therapeutically effective amount of a cytochrome P450 inhibitor.
摘要翻译: 本发明涉及一种用于改善含有六氢呋喃并[2,3-b]呋喃的HIV蛋白酶抑制剂的药代动力学的方法,其包括向有需要的人施用治疗有效量的六氢呋喃并[2,3-b] 含有呋喃基的HIV蛋白酶抑制剂和治疗有效量的细胞色素P450抑制剂。