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公开(公告)号：US20050266003A1
公开(公告)日：2005-12-01
申请号：US11125837
申请日：2005-05-10
申请人： Rong-Hwa Lin , Chung Chang , Pei-Jiun Chen , Chiu-Chen Huang
发明人： Rong-Hwa Lin , Chung Chang , Pei-Jiun Chen , Chiu-Chen Huang
IPC分类号： A61K39/395 , C07K16/28 , C12N15/13
CPC分类号： C07K16/2896 , C07K16/28 , C07K16/3061 , C07K16/462 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are methods of inducing death of an activated T-cell and of modulating a T cell-mediated immune response in a subject.
摘要翻译： 具有结合P-选择蛋白糖蛋白配体-1的抗体的轻链或重链互补决定区的免疫球蛋白链或抗体。 还公开了诱导活化的T细胞死亡和调节受试者中T细胞介导的免疫应答的方法。
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公开(公告)号：US20130102762A1
公开(公告)日：2013-04-25
申请号：US13616849
申请日：2012-09-14
申请人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
发明人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
CPC分类号： C07K16/2896 , C07K16/28 , C07K16/3061 , C07K16/462 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are methods of inducing death of an activated T-cell and of modulating a T cell-mediated immune response in a subject.
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公开(公告)号：US20090198044A1
公开(公告)日：2009-08-06
申请号：US12399516
申请日：2009-03-06
申请人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
发明人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
IPC分类号： C07K16/18
CPC分类号： C07K16/2896 , C07K16/28 , C07K16/3061 , C07K16/462 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are methods of inducing death of an activated T-cell and of modulating a T cell-mediated immune response in a subject.
摘要翻译： 具有结合P-选择蛋白糖蛋白配体-1的抗体的轻链或重链互补决定区的免疫球蛋白链或抗体。 还公开了诱导活化的T细胞死亡和调节受试者中T细胞介导的免疫应答的方法。
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公开(公告)号：US20090191204A1
公开(公告)日：2009-07-30
申请号：US12399484
申请日：2009-03-06
申请人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
发明人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
IPC分类号： A61K39/395 , C12N5/06
CPC分类号： C07K16/2896 , C07K16/28 , C07K16/3061 , C07K16/462 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are methods of inducing death of an activated T-cell and of modulating a T cell-mediated immune response in a subject.
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5.发明授权Anti-PSGL-1 antibodies and methods of inducing cell death of an activated T cell 有权抗PSGL-1抗体和诱导活化的T细胞的细胞死亡的方法公开(公告)号：US08828397B2
公开(公告)日：2014-09-09
申请号：US13616801
申请日：2012-09-14
申请人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
发明人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
IPC分类号： A61K39/395 , C07K16/28 , C07K16/46
CPC分类号： C07K16/2896 , C07K16/28 , C07K16/3061 , C07K16/462 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are methods of inducing death of an activated T-cell and of modulating a T cell-mediated immune response in a subject.
摘要翻译： 具有结合P-选择蛋白糖蛋白配体-1的抗体的轻链或重链互补决定区的免疫球蛋白链或抗体。 还公开了诱导活化的T细胞死亡和调节受试者中T细胞介导的免疫应答的方法。
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公开(公告)号：US20110172397A1
公开(公告)日：2011-07-14
申请号：US12858110
申请日：2010-08-17
申请人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
发明人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , C07K16/28 , C07K16/3061 , C07K16/462 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are methods of inducing death of an activated T-cell and of modulating a T cell-mediated immune response in a subject.
摘要翻译： 具有结合P-选择蛋白糖蛋白配体-1的抗体的轻链或重链互补决定区的免疫球蛋白链或抗体。 还公开了诱导活化的T细胞死亡和调节受试者中T细胞介导的免疫应答的方法。
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公开(公告)号：US20130101587A1
公开(公告)日：2013-04-25
申请号：US13616801
申请日：2012-09-14
申请人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
发明人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , C07K16/28 , C07K16/3061 , C07K16/462 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are methods of inducing death of an activated T-cell and of modulating a T cell-mediated immune response in a subject.
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公开(公告)号：US08663641B2
公开(公告)日：2014-03-04
申请号：US13616849
申请日：2012-09-14
申请人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
发明人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
IPC分类号： A61K39/395
CPC分类号： C07K16/2896 , C07K16/28 , C07K16/3061 , C07K16/462 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are methods of inducing death of an activated T-cell and of modulating a T cell-mediated immune response in a subject.
摘要翻译： 具有结合P-选择蛋白糖蛋白配体-1的抗体的轻链或重链互补决定区的免疫球蛋白链或抗体。 还公开了诱导活化的T细胞死亡和调节受试者中T细胞介导的免疫应答的方法。
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公开(公告)号：US08361472B2
公开(公告)日：2013-01-29
申请号：US12858110
申请日：2010-08-17
申请人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
发明人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2896 , C07K16/28 , C07K16/3061 , C07K16/462 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are methods of inducing death of an activated T-cell and of modulating a T cell-mediated immune response in a subject.
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10.发明授权Methods of inducing cell death of an activated T cell with anti-PSGL-1 antibodies 有权用抗PSGL-1抗体诱导活化的T细胞的细胞死亡的方法公开(公告)号：US08287871B2
公开(公告)日：2012-10-16
申请号：US12399484
申请日：2009-03-06
申请人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
发明人： Rong-Hwa Lin , Chung Nan Chang , Pei-Jiun Chen , Chiu-Chen Huang
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2896 , C07K16/28 , C07K16/3061 , C07K16/462 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are methods of inducing death of an activated T-cell and of modulating a T cell-mediated immune response in a subject.
摘要翻译： 具有结合P-选择蛋白糖蛋白配体-1的抗体的轻链或重链互补决定区的免疫球蛋白链或抗体。 还公开了诱导活化的T细胞死亡和调节受试者中T细胞介导的免疫应答的方法。
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