公开(公告)号：US20120244134A1

公开(公告)日：2012-09-27

申请号：US13186176

申请日：2011-07-19

申请人： Ru-Yin CHEN ,  Chung-Jen CHEN ,  Yi-Jie TSAI ,  Jia-Jiu WU ,  Chih-Ping HUANG ,  Chung-Liang CHU

发明人： Ru-Yin CHEN ,  Chung-Jen CHEN ,  Yi-Jie TSAI ,  Jia-Jiu WU ,  Chih-Ping HUANG ,  Chung-Liang CHU

IPC分类号： A61K38/43 ,  A61K31/07 ,  A61K31/59 ,  A61K31/01 ,  A61K31/355 ,  A61K31/015 ,  A61K31/047 ,  A61K31/357 ,  A61K31/7048 ,  A61K9/14 ,  A23L3/3553 ,  A61K47/24 ,  A61K31/12 ,  B82Y5/00

CPC分类号： A23L33/15 ,  A23L29/10 ,  A23L33/10 ,  A23L33/105

摘要： The present invention provides a process for preparing an aqueous dispersion containing a high concentration of nano/submicron, hydrophobic, functional compounds. The process is carried out by using a complex stabilizer having an HLB value of about 10 to about 17, comprising lecithin and at least one non-phospholipid selected from polysorbate, sucrose ester, and polyglycerol fatty acid ester; selecting a specific weight ratio of the hydrophobic functional compounds and the stabilizer; and using homogenization technique, media milling technique, and/or centrifugal technique. The aqueous dispersion containing a high concentration of nano/submicron, hydrophobic, functional compound produced by the process of the invention has stable dispersibility and improved bioavailability, and can be applied to the fields of foods and pharmaceuticals.

摘要翻译： 本发明提供一种制备含有高浓度纳米/亚微米疏水功能化合物的水性分散体的方法。 该方法通过使用HLB值为约10至约17的复合稳定剂，包括卵磷脂和至少一种选自聚山梨醇酯，蔗糖酯和聚甘油脂肪酸酯的非磷脂; 选择疏水官能化合物和稳定剂的特定重量比; 并使用均质技术，介质研磨技术和/或离心技术。 含有本发明方法生产的高浓度纳米/亚微米疏水功能化合物的水分散体具有稳定的分散性和改善的生物利用度，可应用于食品和药物领域。